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Matrix metalloproteinase-2 delivery to extracellular vesicles produced by HPV-positive cervical cancer cells enhances metastasis via the Akt pathway
Cell Biol Int. 2023 Jun 5. doi: 10.1002/cbin.12054. Online ahead of print.ABSTRACTHere, we aimed to analyze the effects of matrix metalloproteinase-2 (MMP-2) delivery to extracellular vesicles (EVs) secreted by human papillomavirus (HPV)-associated cervical cancer cells on human umbilical vein endothelial cell (HUVEC) angiogenesis. First, MMP-2 expression was compared among SiHa (HPV16), HeLa (HPV18), and C-33A (negative) cells. Then, EVs were isolated from these cells, and MMP-2 expression in the EVs was compared. SiHa and HeLa cells were transfected with MMP-2 or control siRNA. HUVECs were treated with EVs isolating from...
Source: Cancer Control - June 5, 2023 Category: Cancer & Oncology Authors: Jianan Sun Junjun Mou Yunmei Zhang Kang Yuan Ying Yang Qing Tang Source Type: research

HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
CONCLUSIONS: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.PMID:35144669 | DOI:10.1186/s13046-022-02258-9
Source: Cancer Control - February 11, 2022 Category: Cancer & Oncology Authors: Simona Citro Claudia Miccolo Alessandro Medda Lavinia Ghiani Marta Tagliabue Mohssen Ansarin Susanna Chiocca Source Type: research

The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells
CONCLUSION: Rap1GAP may be degraded by autophagy in cervical cancer cells, but HPV infection can switch the degradation pathway from autophagy to E6AP-mediated ubiquitin-proteasome degradation. E6AP may be a key component of the switch.PMID:34952616 | DOI:10.1186/s13027-021-00409-9
Source: Cancer Control - December 25, 2021 Category: Cancer & Oncology Authors: Yinghui Wang Yihang Xie Boxuan Sun Yuwei Guo Ling Song Dawit Eman Mohammednur Chunyan Zhao Source Type: research