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Downregulation of Sonic hedgehog signaling induces G2-arrest in genital warts
CONCLUSIONS: The downregulation of the SHh signaling promotes HPV replication and the formation of warts by inducing G2/M arrest in the keratinocytes of CA.PMID:36704875 | DOI:10.1111/srt.13265
Source: Cell Research - January 27, 2023 Category: Cytology Authors: Xiangxi Du Shan Li Kun Yang Yuchun Cao Source Type: research

The Significance of CD109 Expression in Oropharyngeal Squamous Cell Carcinoma
CONCLUSION: CD109 expression is associated with poor prognosis of HPV16+ OPSCCs.PMID:35347029 | DOI:10.21873/anticanres.15687
Source: Cell Research - March 29, 2022 Category: Cytology Authors: Shohei Tsutsumi Kaho Momiyama Masaaki Ichinoe Takuya Kato Sachiyo Mogi Shunsuke Miyamoto Yoshiki Murakumo Taku Yamashita Source Type: research

HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
CONCLUSIONS: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.PMID:35144669 | DOI:10.1186/s13046-022-02258-9
Source: Cell Research - February 11, 2022 Category: Cytology Authors: Simona Citro Claudia Miccolo Alessandro Medda Lavinia Ghiani Marta Tagliabue Mohssen Ansarin Susanna Chiocca Source Type: research