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Short interfering RNA in colorectal cancer: is it wise to shoot the messenger?
This study focuses on many innovative siRNA therapies and methodologies for delivering siRNA therapeutics to the malignant site safely and effectively for the treatment of CRC. Treatment of CRC using siRNA-associated nanoparticles (NPs) may inhibit the activity of oncogenes and MDR-related genes by targeting a range of signaling mechanisms. This study summarizes several siRNAs targeting signaling molecules, as well as the therapeutic approaches that might be employed to treat CRC in the future.PMID:37011722 | DOI:10.1016/j.ejphar.2023.175699
Source: European Journal of Pharmacology - April 3, 2023 Category: Drugs & Pharmacology Authors: Kiruthiga Chandramohan Devasahayam Jaya Balan Kasi Pandima Devi Seyed Fazel Nabavi Sara Reshadat Maryam Khayatkashani Sepideh Mahmoodifar Rosanna Filosa Nilofar Amirkhalili Soroush Pishvaei Omolbanin Sargazi Aval Seyed Mohammad Nabavi Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research