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N protein of PEDV plays chess game with host proteins by selective autophagy
In this study, we have found a novel host restriction factor, HNRNPA1, that could inhibit PEDV replication by degrading viral nucleocapsid (N) protein. The restriction factor activates the HNRNPA1-MARCHF8/MARCH8-CALCOCO2/NDP52-autophagosome pathway with the help of transcription factor EGR1 targeting the HNRNPA1 promoter. HNRNPA1 could also promote the expression of IFN to facilitate the host antiviral defense response for antagonizing PEDV infection through RIGI protein interaction. During viral replication, we found that PEDV can, in contrast, degrade the host antiviral proteins HNRNPA1 and others (FUBP3, HNRNPK, PTBP1, ...
Source: Autophagy - March 2, 2023 Category: Cytology Authors: Xueying Zhai Ning Kong Yu Zhang Yiyi Song Wenzhen Qin Xinyu Yang Chenqian Ye Manqing Ye Wu Tong Changlong Liu Hao Zheng Hai Yu Wen Zhang Xia Yang Gaiping Zhang Guangzhi Tong Tongling Shan Source Type: research