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Infectious Disease: H1N1
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Total 17 results found since Jan 2013.
Global Human-Kinase Screening Identifies Therapeutic Host Targets against Influenza
During viral infection of human cells, host kinases mediate signaling activities that are used by all viruses for replication; therefore, targeting of host kinases is of broad therapeutic interest. Here, host kinases were globally screened during human influenza virus (H1N1) infection to determine the time-dependent effects of virus infection and replication on kinase function. Desthiobiotin-labeled analogs of adenosine triphosphate and adenosine diphosphate were used to probe and covalently label host kinases in infected cell lysates, and probe affinity was determined. Using infected human A549 cells, we screened for time...
Source: Journal of Biomolecular Screening - June 24, 2014 Category: Molecular Biology Authors: Atkins, C., Evans, C. W., Nordin, B., Patricelli, M. P., Reynolds, R., Wennerberg, K., Noah, J. W. Tags: Original Research Source Type: research
Optimised design of siRNA based on multi-featured comparison and analysis of H1N1 virus.
In this study, we developed a computational method for designing therapeutics siRNA and applied in the recent HIN1 influenza virus based on its biological characteristics that are substantially different from seasonal influenza virus. We first compared the PA fragments between the H IN1 virus in 2009 and the seasonal influenza virus genes in 2008, and the comparison found significant differences between them not only in sequence features but also in RNA secondary structures. In particular, the RNA secondary structures only share 76.8% identity, which suggests major changes in biological characteristics. Furthermore, we des...
Source: International Journal of Data Mining and Bioinformatics - June 29, 2013 Category: Bioinformatics Authors: Liu Y, Chang Y, Xu D, Li Z, Zhang H, Li J, Tian M Tags: Int J Data Min Bioinform Source Type: research
