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Induction of RNA interference to block Zika virus replication and transmission in the mosquito Aedes aegypti.
This study lays critical groundwork for pursuing ZIKV transmission-blocking strategies that exploit the Ae. aegypti exo-siRNA response for arbovirus suppression in natural populations. PMID: 31103782 [PubMed - as supplied by publisher]
Source: Insect Biochemistry and Molecular Biology - May 15, 2019 Category: Biochemistry Authors: Magalhaes T, Bergren NA, Bennett SL, Borland EM, Hartman DA, Lymperopoulos K, Sayre R, Borlee BR, Campbell CL, Foy BD, Olson KE, Blair CD, Black W, Kading RC Tags: Insect Biochem Mol Biol Source Type: research

Proteomic Profiling of Chikungunya Virus-Infected Human Muscle Cells: Reveal The Role of Cytoskeleton Network in CHIKV Replication.
Abstract Chikungunya virus (CHIKV) is an arthropod-borne, positive-sense, single-stranded RNA virus belonging to genus Alphavirus and family Togaviridae. The clinical manifestations developed upon CHIKV-infection include fever, myositis, arthralgia and maculopapular rash. Thus, the re-emergence of CHIKV has posed serious health threats worldwide. Due to the fact that myositis is induced upon CHIKV-infection, we sought to understand the dynamic proteomic regulation in SJCRH30, a human rhabdomyosarcoma cell line, to gain insights on CHIKV pathogenesis. Two-dimensional gel electrophoresis (2DE) in combination of matr...
Source: Journal of Proteomics - June 13, 2014 Category: Biochemistry Authors: Issac TH, Lee TE, Chu JJ Tags: J Proteomics Source Type: research