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Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts.
Abstract Arboviruses represent an emerging threat to human. They are transmitted to vertebrates by the bite of infected arthropods. Early transmission to vertebrates is initiated by skin puncture and deposition of virus in this organ. However, events at the bite site remain largely unknown. Here, we report that Chikungunya virus (CHIKV) and West Nile virus (WNV), despite belonging to distinct viral families, elicit a common antiviral signature in primary human dermal fibroblasts, attesting for the up regulation of interferon signalling pathways and leading to an increased expression of IFN-β, interleukins and che...
Source: Infection, Genetics and Evolution - April 3, 2015 Category: Genetics & Stem Cells Authors: Ekchariyawat P, Hamel R, Bernard E, Wichit S, Surasombatpattana P, Talignani L, Thomas F, Choumet V, Yssel H, Desprès P, Briant L, Missé D Tags: Infect Genet Evol Source Type: research