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Viruses, Vol. 14, Pages 1628: Inhibition of Venezuelan Equine Encephalitis Virus Using Small Interfering RNAs
In this study, novel vsiRNAs that targeted conserved regions in the nonstructural and structural genes of the VEEV genome were designed and evaluated for antiviral activity in mammalian cells in the context of VEEV infection. The data demonstrate that vsiRNAs were able to effectively decrease the infectious virus titer at earlier time points post infection in the context of the attenuated TC-83 strain and the virulent Trinidad Donkey strain, while the inhibition was overcome at later time points. Depletion of Argonaute 2 protein (Ago2), the catalytic component of the RISC complex, negated the inhibitory effect of the vsiRN...
Source: Viruses - July 26, 2022 Category: Virology Authors: Amrita Haikerwal Michael D. Barrera Nishank Bhalla Weidong Zhou Niloufar Boghdeh Carol Anderson Farhang Alem Aarthi Narayanan Tags: Article Source Type: research