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Recent advances on therapeutic potentials of gold and silver nanobiomaterials for human viral diseases
Curr Res Chem Biol. 2022;2:100021. doi: 10.1016/j.crchbi.2022.100021. Epub 2022 Feb 1.ABSTRACTViral diseases are prominent among the widely spread infections threatening human well-being. Real-life clinical successes of the few available therapeutics are challenged by pathogenic resistance and suboptimal delivery to target sites. Nanotechnology has aided the design of functionalised and non-functionalised Au and Ag nanobiomaterials through physical, chemical and biological (green synthesis) methods with improved antiviral efficacy and delivery. In this review, innovative designs as well as interesting antiviral activities ...
Source: Herpes - July 11, 2022 Category: Infectious Diseases Authors: Yusuf Oloruntoyin Ayipo Ajibola Abdulahi Bakare Umar Muhammad Badeggi Akeem Adebayo Jimoh Amudat Lawal Mohd Nizam Mordi Source Type: research

Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation
by Simon Dirmeier, Christopher D ächert, Martijn van Hemert, Ali Tas, Natacha S. Ogando, Frank van Kuppeveld, Ralf Bartenschlager, Lars Kaderali, Marco Binder, Niko Beerenwinkel Genetic perturbation screens using RNA interference (RNAi) have been conducted successfully to identify host factors that are essential for the life cycle of bacteria or viruses. So far, most published studies identified host factors primarily for single pathogens. Furthermore, often only a small subset of genes, e.g., genes encoding kinases, have been targeted. Identification of host factors on a pan-pathogen level, i.e., genes that are crucial ...
Source: PLoS Computational Biology - February 9, 2020 Category: Biology Authors: Simon Dirmeier Source Type: research