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p16 and Gigaxonin Mediated Ubiquitination of NF{kappa}B Molecular Bases of Disease
The molecular mechanism of p16-mediated senescence in cisplatin-treated cancer cells is not fully understood. Here we show that cisplatin treatment of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modification of NFκB. Chromatin immunoprecipitation assays show that this modification is associated with the inhibition of NFκB interacting with its DNA binding sequences, leading to decreased expression of NFκB-transcribed proteins. LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetracycline-inducible GFP-S peptide-NFκB expression system identified g...
Source: Journal of Biological Chemistry - December 11, 2014 Category: Chemistry Authors: Veena, M. S., Wilken, R., Zheng, J.-Y., Gholkar, A., Venkatesan, N., Vira, D., Ahmed, S., Basak, S. K., Dalgard, C. L., Ravichandran, S., Batra, R. K., Kasahara, N., Elashoff, D., Fishbein, M. C., Whitelegge, J. P., Torres, J. Z., Wang, M. B., Srivatsan, Tags: Cell Biology Source Type: research
