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Short interfering RNA induced generation and translation of stable 5 ′ mRNA cleavage intermediates
Publication date: August 2016 Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1859, Issue 8 Author(s): Richa Singhania, Sandra Pavey, Elizabeth Payne, Wenyi Gu, Jennifer Clancy, Luqman Jubair, Thomas Preiss, Nicholas Saunders, Nigel A.J. McMillan Sequence-specific degradation of homologous mRNA is the main mechanism by which short-interfering RNAs (siRNAs) suppress gene expression. Generally, it is assumed that the mRNA fragments resulting from Ago2 cleavage are rapidly degraded, thus making the transcript translation-incompetent. However, the molecular mechanisms involved in the post-cleav...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - August 6, 2016 Category: Genetics & Stem Cells Source Type: research

Short interfering RNA induced generation and translation of stable 5 ’ mRNA cleavage intermediates
Publication date: Available online 16 June 2016 Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Author(s): Richa Singhania, Sandra Pavey, Elizabeth Payne, Wenyi Gu, Jennifer Clancy, Luqman Jubair, Thomas Preiss, Nicholas Saunders, Nigel A.J. McMillan Sequence-specific degradation of homologous mRNA is the main mechanism by which short-interfering RNAs (siRNAs) suppress gene expression. Generally, it is assumed that the mRNA fragments resulting from Ago-2 cleavage are rapidly degraded, thus making the transcript translation-incompetent. However, the molecular mechanisms involved in the pos...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - June 17, 2016 Category: Genetics & Stem Cells Source Type: research

Short interfering RNA induced generation and translation of stable 5’ mRNA cleavage intermediates
Publication date: Available online 16 June 2016 Source:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Author(s): Richa Singhania, Sandra Pavey, Elizabeth Payne, Wenyi Gu, Jennifer Clancy, Luqman Jubair, Thomas Preiss, Nicholas Saunders, Nigel A.J. McMillan Sequence-specific degradation of homologous mRNA is the main mechanism by which short-interfering RNAs (siRNAs) suppress gene expression. Generally, it is assumed that the mRNA fragments resulting from Ago-2 cleavage are rapidly degraded, thus making the transcript translation-incompetent. However, the molecular mechanisms involved in the pos...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - June 16, 2016 Category: Genetics & Stem Cells Source Type: research