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Condition: G6PD
Infectious Disease: Human Papillomavirus (HPV)
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Total 1 results found since Jan 2013.
miR-1 inhibits progression of high-risk papillomavirus-associated human cervical cancer by targeting G6PD.
Authors: Hu T, Chang YF, Xiao Z, Mao R, Tong J, Chen B, Liu GC, Hong Y, Chen HL, Kong SY, Huang YM, Xiyang YB, Jin H
Abstract
Ectopic glucose-6-phosphate dehydrogenase (G6PD) expression may contribute to tumorigenesis in cervical cancer associated with high-risk human papillomavirus (HR-HPV 16 and 18) infections. Here, we demonstrate that microRNA-1 (miR-1) in association with AGO proteins targets G6PD in HR-HPV-infected human cervical cancer cells. miR-1 inhibited expression of a reporter construct containing a putative G6PD 3'-UTR seed region and suppressed endogenous G6PD expression. Down-regulation of miR-1 inc...
Source: Oncotarget - November 20, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
