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Source: Molecules
Condition: Parkinson's Disease
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Molecules, Vol. 27, Pages 3151: Neuroprotective Effect of Dioscin against Parkinson & rsquo;s Disease via Adjusting Dual-Specificity phosphatase 6(DUSP6)-Mediated Oxidative Stress
In this study, the tests on 6-hydroxydopamine (6-OHDA)-induced PC12 cells and rats were carried out. The results showed that dioscin dramatically improved cell viability, decreased reactive oxygen species (ROS) levels, improved motor behavior and tyrosine hydroxylase(TH) levels and restored the levels of glutathione (GSH) and malondialdehyde (MDA) in rats. Mechanism investigation showed that dioscin not only markedly increased the expression level of dual- specificity phosphatase 6 (DUSP6) by 1.87-fold in cells and 2.56-fold in rats, and decreased phospho-extracellular regulated protein kinases (p-ERK) level by 2.12-fold i...
Source: Molecules - May 14, 2022 Category: Chemistry Authors: Zhang Mao Meng Gao Xuerong Zhao Lili Li Jinyong Peng Tags: Article Source Type: research
