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Molecules, Vol. 26, Pages 901: Silencing ZEB2 Induces Apoptosis and Reduces Viability in Glioblastoma Cell Lines
Conclusions: In line with previous investigations, our results indicated a critical oncogenic role for ZEB2 overexpression in brain glioma tumors. These properties make ZEB2 an essential molecule for further studies in the treatment of glioma cancer.
Source: Molecules - February 9, 2021 Category: Chemistry Authors: Sahar Safaee Masoumeh Fardi Nima Hemmat Neda Khosravi Afshin Derakhshani Nicola Silvestris Behzad Baradaran Tags: Article Source Type: research

Molecules, Vol. 23, Pages 2028: Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery
Malkoch Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1–G4), modified to bear 6–48 amino end-groups, where the G2–G4 proved to be capable of siRNA complexation and protection against RNase-mediated degradation. The dendrimers were nontoxic to astrocytes, glioma (C6), and glioblastoma (U87), while G3 and G4 exhibited concentration dependent toxicity towards primary ...
Source: Molecules - August 14, 2018 Category: Chemistry Authors: Patrik Stenstr öm Dario Manzanares Yuning Zhang Valentin Ce ña Michael Malkoch Tags: Article Source Type: research