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Molecules, Vol. 27, Pages 8457: CD70-Targeted Micelles Enhance HIF2 & alpha; siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells
Molecules, Vol. 27, Pages 8457: CD70-Targeted Micelles Enhance HIF2α siRNA Delivery and Inhibit Oncogenic Functions in Patient-Derived Clear Cell Renal Carcinoma Cells
Molecules doi: 10.3390/molecules27238457
Authors:
Noah Trac
Hyun Seok Oh
Leila Izzy Jones
Randy Caliliw
Shinji Ohtake
Brian Shuch
Eun Ji Chung
The majority of clear cell renal cell carcinomas (ccRCCs) are characterized by mutations in the Von Hippel–Lindau (VHL) tumor suppressor gene, which leads to the stabilization and accumulation of the HIF2α transcription factor that upregulates key oncogenic pat...
Source: Molecules - December 2, 2022 Category: Chemistry Authors: Noah Trac Hyun Seok Oh Leila Izzy Jones Randy Caliliw Shinji Ohtake Brian Shuch Eun Ji Chung Tags: Article Source Type: research
