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Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells.
Authors: Nagahara T, Shiraha H, Sawahara H, Uchida D, Takeuchi Y, Iwamuro M, Kataoka J, Horiguchi S, Kuwaki T, Onishi H, Nakamura S, Takaki A, Nouso K, Yamamoto K Abstract Microenvironment plays an important role in epithelial-mesenchymal transition (EMT) and stemness of cells in hepatocellular carcinoma (HCC). Epithelial cell adhesion molecule (EpCAM) is known as a tumor stemness marker of HCC. To investigate the relationship between microenvironment and stemness, we performed an in vitro co-culture assay. Four HCC cell lines (HepG2, Hep3B, HuH-7 and PLC/PRF/5) were co-cultured with the TWNT-1 immortalized hepati...
Source: Oncology Reports - July 15, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-205 inhibits the proliferation and invasion of breast cancer by regulating AMOT expression.
Authors: Zhang H, Fan Q Abstract It has been reported that the expression of angiomotin (AMOT) is upre-gulated in breast cancer. However, the regulatory mechanism remains unknown. In the present study, we aimed to ascertain whether the expression of AMOT is regulated by microRNAs (miRNAs) in breast cancer. In the present study, miR-205 was significantly downregulated in breast cancer samples and it was identified to directly target the 3'-untranslated region (3'-UTR) of AMOT in breast cancer MCF-7 cells by luciferase assay. miR-205 and small interfering RNA (siRNA)-mediated AMOT-knockdown experiments revealed that...
Source: Oncology Reports - August 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Simvastatin protects Sertoli cells against cisplatin cytotoxicity through enhanced gap junction intercellular communication.
Authors: Wang L, Peng J, Huang H, Wang Q, Yu M, Tao L Abstract Cisplatin, an important chemotherapeutic agent against testicular germ cell cancer, induces testicular toxicity on Leydig and Sertoli cells, leading to serious side-effects such as azoospermia and infertility. In a previous study, it was found that simvastatin enhanced the sensitivity of Leydig tumor cells to chemotherapeutic toxicity through the enhancement of gap junction functions. In the present study, the effect of simvastatin on the sensitivity of normal Sertoli cells to cisplatin and the role of gap junctions in such effects was investigated. T...
Source: Oncology Reports - August 15, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Promoting roles of the secreted frizzled-related protein 2 as a Wnt agonist in lung cancer cells.
Authors: Xiao X, Xiao Y, Wen R, Zhang Y, Li X, Wang H, Huang J, Liu J, Long T, Tang J Abstract The secreted frizzled-related protein 2 (SFRP2) plays a pivotal role in the Wnt pathway, however, it functions as an agonist or an antagonist is still controversial. We profiled SFRP2 expression in several lung cancer cell lines, and found that A549 and 95-D exhibited the lowest and the highest level of SFRP2, respectively. Then we employed the SFRP2-overexpressing plasmid and siRNA to transfect A549 and 95-D cells, respectively. Through MTT assays, we found that SFRP2 knockdown inhibited cell proliferation, and halted th...
Source: Oncology Reports - September 3, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mitogen-activated protein kinase phosphatase 1 is involved in tamoxifen resistance in MCF7 cells.
Authors: Ma G, Pan Y, Zhou C, Sun R, Bai J, Liu P, Ren Y, He J Abstract Tamoxifen resistance is a major clinical problem for ER-positive breast cancer, but the underlying mechanism is not completely elucidated. In the present study, we reported that mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1), a member of the family of MKPs, is involved in tamoxifen resistance. We found that MKP1 expression increased in tamoxifen resistant MCF7 cells. To explore the possible role of MKP1 in tamoxifen resistance, siRNA targeting MKP1 was transfected into tamoxifen resistant MCF7 cells. To our surprise, knockdown...
Source: Oncology Reports - September 6, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Increased efficiency of testicular tumor chemotherapy by ultrasound microbubble-mediated targeted transfection of siMDR1.
Authors: He Y, Bi Y, Ji XJ, Wei G Abstract The MDR1 gene encoding P-glycoprotein (P-gp) is an ATP-dependent drug efflux transporter and is related to drug resistance of yolk sac tumors. Drug resistence may be an important factor for the low efficiency of chemotherapy in the treatment of testicular tumors. P-gp, encoded by the MDR1 gene, is an ATP-binding cassette transporter. P-gp exhibits high expression in capillary endothelial cells of the testis and prevents the intracellular accumulation of chemotherapy agents in testicular tumor cells, resulting in drug resistance. In the present study, we aimed to use specif...
Source: Oncology Reports - September 11, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Downregulation of NOB1 inhibits proliferation and promotes apoptosis in human oral squamous cell carcinoma.
Authors: Yin J, Wang J, Jiang Y, Wang L, Wu H, Liu H Abstract NIN1/RPN12 binding protein 1 homolog (NOB1) facilitates the maturation of the 20S proteasome and is then degraded by 26S proteasome to complete 26S proteasome biogenesis. It also accompanies the pre-40S ribosomes during nuclear export and is cleaved at D-site of 20S pre-rRNA to form mature 18S rRNA in growing cells. NOB1 was reported to be involved in the development of several types of cancer. However, the role of NOB1 in oral squamous cell carcinoma (OSCC) has not been addressed. In the present study, the expression of NOB1 in 50 OSCC patients with di...
Source: Oncology Reports - September 18, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miRNA expression profile of vulvar squamous cell carcinoma and identification of the oncogenic role of miR-590-5p.
In conclusion, we present the miRNA expression profile in VSCC, and our findings suggest that the upregulation of miR‑590‑5p promotes cellular malignant behaviours via the target gene TGFβRⅡ. PMID: 26498065 [PubMed - as supplied by publisher]
Source: Oncology Reports - October 28, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma.
Authors: Yan L, Wang Y, Wang ZZ, Rong YT, Chen LL, Li Q, Liu T, Chen YH, Li YD, Huang ZH, Peng J Abstract Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. However, few studies have defined functional roles and mechanisms of action. In the present study, the relationship between clinical and pathological parameters was also analyzed. The relative CEACAM6 protein expression of pancreatic carcinoma was significant...
Source: Oncology Reports - October 28, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Expression of ADAM12 is regulated by E2F1 in small cell lung cancer.
Authors: Li Z, Wang Y, Kong L, Yue Z, Ma Y, Chen X Abstract Our previous study reported that ADAM12 was highly expressed in small cell lung cancer (SCLC) and could be an effective marker for diagnosis and prognosis. Yet, the reason for the high expression of ADAM12 in SCLC requires further elucidation. Transcription factor E2F1 has been receiving increasing attention due to the complexity and diversity of its function in cancer. In the present study, the expression of ADAM12 was significantly decreased following silencing of E2F1 expression by siRNA, thus indicating that E2F1 may regulate the expression of ADAM12 a...
Source: Oncology Reports - October 30, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells.
In conclusion, Cks1 and Cks2 promoted proliferation and prevented apoptosis of HepG2 cells. The Akt/GSK-3β-related PI3K/Akt signaling pathway may be a key signaling pathway that is involved in the regulation of cell growth and cell death. PMID: 26531156 [PubMed - as supplied by publisher]
Source: Oncology Reports - November 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN‑regulated PI3K/Akt signaling pathway.
Authors: Jing X, Cheng W, Wang S, Li P, He L Abstract Resveratrol is a polyphenolic compound that is extracted from Polygonum cuspidatum and is used in traditional Chinese medicine. Previous data have shown that resveratrol inhibits the growth of human gastric cancer. MTT [3-(4,5-dimethylthiazol-2-yl)‑2,5-diphenyl tetrazolium bromide] and trypan blue assays showed that resveratrol significantly decreased the survival rate of MGC803 cells in a concentration‑ and time‑dependent manner. Our flow cytometric analysis showed that resveratrol treatment arrested the cells at the G0/G1 phase of the cell cycle. Further...
Source: Oncology Reports - November 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells.
Authors: Du C, Wang X, Zhang J, Liu X, Zhu J, Liu Y Abstract Paxillin (PXN) encodes a 68-kDa focal adhesion-associated protein and plays an important role in signal transduction, regulation of cell morphology, migration, proliferation and apoptosis. The aim of the present study was to evaluate the relationship between PXN and clinicopathological factors in colorectal cancer, the role of PXN in cetuximab resistance, and whether knockdown of PXN expression could improve the sensitivity to cetuximab in colorectal cancer cells. In the present study, immunohistochemical staining in 148 colorectal carcinoma and 126 nor...
Source: Oncology Reports - November 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Esophageal squamous cell carcinoma cell proliferation induced by exposure to low concentration of cigarette smoke extract is mediated via targeting miR-101-3p/COX-2 pathway.
Authors: Gong J, Chu Y, Xu M, Huo J, Lv L Abstract Cigarette smoke has been implicated as a major risk factor for esophageal squamous cell carcinoma (ESCC). Several lines of evidence have suggested that the promoting effect of cigarette smoking extract (CSE) on ESCC is mediated by upregulation of cyclooxygenase-2 (COX-2) expression. Yet, the underlying molecular and cellular mechanisms of how CSE stimulates COX-2 expression and facilitates ESCC development are largely unknown. In the present study, we revealed microRNA (miR)-101-3p expression was downregulated upon exposure to low concentration of CSE in Eca109 can...
Source: Oncology Reports - November 7, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer.
Authors: Xu C, Li S, Chen T, Hu H, Ding C, Xu Z, Chen J, Liu Z, Lei Z, Zhang HT, Li C, Zhao J Abstract Polo-like kinase 1 (PLK1), a critical kinase for mitotic progression, is overexpressed in a wide range of cancers. MicroRNAs (miRNAs) are a class of small non-coding RNA molecules and proposed to play important roles in the regulation of tumor progression and invasion. However, the relationship between PLK1 and miRNAs have remained unclear. In the present study, the association between PLK1 and miR-296-5p was investigated. The upregulation of PLK1 mRNA expression levels combined with the downregulation of miR-296-...
Source: Oncology Reports - November 11, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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