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Source: Theranostics
Therapy: Stem Cell Therapy
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Total 17 results found since Jan 2013.
An exosomal-carried short periostin isoform induces cardiomyocyte proliferation
Conclusions: Our results show, for the first time, that CPC-secreted exosomes promote cardiomyocyte cell cycle-reentry via a short periostin isoform expressed on their surfaces, whereas recombinant full-length periostin does not. These findings highlight isoform-specific roles of periostin in cardiomyocyte proliferation.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Carolina Balbi, Giuseppina Milano, Tudor E. Fertig, Edoardo Lazzarini, Sara Bolis, Yoshiaki Taniyama, Fumihiro Sanada, Dario Di Silvestre, Pierluigi Mauri, Mihaela Gherghiceanu, Thomas F. L ü scher, Lucio Barile, Giuseppe Vassalli Tags: Research Paper Source Type: research
Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging
Conclusion: Toward translational medicine, this study hints that targeting lnc-PMIF to facilitate aged OPCs migrating to bone formation surface could be a brand-new anabolic strategy for aging-related osteoporosis.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Dijie Li, Jin Liu, Chaofei Yang, Ye Tian, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Ru Zhang, Aiping Lu, Ge Zhang, Airong Qian Tags: Research Paper Source Type: research
CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3 β / β -catenin/OCT4 axis
Conclusions: We identified a potential CSC regulator and suggest a novel mechanism for how CCL16 governs cancer cell stemness. We propose that CCL16 could be an effective target for breast cancer therapy.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Wenzhi Shen, Xiaoyuan Zhang, Jiaping Tang, Zhixin Zhang, Renle Du, Dehong Luo, Xiaoran Liu, Yong Xia, Yanping Li, Shanshan Wang, Siyuan Yan, Wancai Yang, Rong Xiang, Na Luo, Yunping Luo, Jianjun Li Tags: Research Paper Source Type: research
Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine
Conclusion: This study provides novel methods for the construction of stem cell microenvironments and experimental models of HF regeneration for the treatment of hair loss.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Peng Chen, Yong Miao, Feifei Zhang, Junfei Huang, Yuxin Chen, Zhexiang Fan, Lunan Yang, Jin Wang, Zhiqi Hu Tags: Research Paper Source Type: research
Stem Cell Factor-Inducible MITF-M Expression in Therapeutics for Acquired Skin Hyperpigmentation
Conclusion: We propose the targeting of SCF/KIT-inducible MITF-M expression as a strategy in the therapeutics for acquired pigmentary disorders.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Cheong-Yong Yun, Eunmiri Roh, Song-Hee Kim, Jinhe Han, Jiyeon Lee, Da-Eun Jung, Ga Hyeon Kim, Sang-Hun Jung, Won-Jea Cho, Sang-Bae Han, Youngsoo Kim Tags: Research Paper Source Type: research
SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer
Conclusion: This study presented a bone-cancer dual-targeting biomimetic nanodelivery system for bone metastatic CRPC.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jiyuan Chen, Zhenjie Wu, Weihong Ding, Chengwu Xiao, Yu Zhang, Shen Gao, Yuan Gao, Weimin Cai Tags: Research Paper Source Type: research
FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells
Conclusions: Our data therefore demonstrate the importance of FGF9 in the determination of SC fate via the FGF9-FGFR2-Akt pathway and reveal the therapeutic benefit of FGF9-NLCs.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Chia-Wei Huang, Shih-Yu Lu, Tzu-Chieh Huang, Bu-Miim Huang, H. Sunny Sun, Shang-Hsun Yang, Jih-Ing Chuang, Yuan-Yu Hsueh, Yi-Ting Wu, Chia-Ching Wu Tags: Research Paper Source Type: research
Targeted sequencing reveals the mutational landscape responsible for sorafenib therapy in advanced hepatocellular carcinoma
Conclusion: Our study reported a novel somatic mutation in OCT4 (c.G52C) responsible for the sorafenib effect, and also shed new light on the treatment of HCC through the combination of specific tyrosine kinase inhibitors according to individual genetic patterns.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Jing Tang, Cheng-Jun Sui, Dong-Fang Wang, Xin-Yuan Lu, Gui-Juan Luo, Qing Zhao, Qiu-Yu Lian, Seogsong Jeong, Xi-Meng Lin, Yan-Jing Zhu, Bo Zheng, Rui Wu, Qing Wang, Xiao-Long Liu, Jing-Feng Liu, Qiang Xia, Gang Wu, Jin Gu, Hong-Yang Wang, Lei Chen Tags: Research Paper Source Type: research
Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway
Conclusions: Using loss/gain-of function method, we demonstrated that miR-421/FOXO3a is the direct target of circHIPK3, and UMSC-Exo prevent ischemic injury by releasing circHIPK3, which in turn down regulate miR-421, resulting in increased expression of FOXO3a, leading to inhibition of pyroptosis and release of IL-1β and IL-18.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Bing Yan, Yu Zhang, Chun Liang, Bin Liu, Fengzhi Ding, Yanli Wang, Bao Zhu, Ranzun Zhao, Xi-Yong Yu, Yangxin Li Tags: Research Paper Source Type: research
ZnAs@SiO2 nanoparticles as a potential anti-tumor drug for targeting stemness and epithelial-mesenchymal transition in hepatocellular carcinoma via SHP-1/JAK2/STAT3 signaling
Conclusions: ZnAs@SiO2 NPs can effectively suppress tumor initiation, growth, metastasis, and inhibit stemness and EMT through regulation of SHP-1/JAK2/STAT3 signaling pathway in liver cancer cells in vitro and in vivo. Thus, ZnAs@SiO2 NPs have immense potential for HCC treatment in the future.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yongquan Huang, Bin Zhou, Hui Luo, Junjie Mao, Yin Huang, Ke Zhang, Chaoming Mei, Yan Yan, Hongjun Jin, Jinhao Gao, Zhongzhen Su, Pengfei Pang, Dan Li, Hong Shan Tags: Research Paper Source Type: research
COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells
Conclusion: These findings indicate that COL4A2 in the ECM promotes osteogenic differentiation of PDLSCs through negative regulation of the Wnt/β-catenin pathway, which can be used as a potential therapeutic strategy to repair bone defects.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Yi Wen, Hongxu Yang, Junjie Wu, Axian Wang, Xiaodong Chen, Sijun Hu, Yuxing Zhang, Ding Bai, Zuolin Jin Tags: Research Paper Source Type: research
Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19
Conclusion: CAFs promote the stemness and chemoresistance of CRC by transferring exosomal H19. H19 activated the β-catenin pathway via acting as a competing endogenous RNA sponge for miR-141, while miR-141 inhibited the stemness of CRC cells. Our findings indicate that H19 expressed by CAFs of the colorectal tumor stroma contributes to tumor development and chemoresistance.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jing Ren, Liang Ding, Dongya Zhang, Guoping Shi, Qianyun Xu, Sunan Shen, Yaping Wang, Tingting Wang, Yayi Hou Tags: Research Paper Source Type: research
XIAP Limits Autophagic Degradation of Sox2 and Is A Therapeutic Target in Nasopharyngeal Carcinoma Stem Cells
Conclusion: Our study highlights the importance of IAPs in the maintenance of CSCs in NPC. Thus, XIAP is a promising therapeutic target in CSCs and suggests that NPC patients may benefit from a combination treatment of APG-1387 with conventional chemotherapy.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Jiao Ji, Yan Yu, Zhi-Ling Li, Ming-Yuan Chen, Rong Deng, Xiang Huang, Guang-Feng Wang, Meng-Xia Zhang, Qi Yang, Senthilkumar Ravichandran, Gong-Kan Feng, Xue-Lian Xu, Chen-Lu Yang, Miao-Zhen Qiu, Lin Jiao, Dajun Yang, Xiao-Feng Zhu Tags: Research Paper Source Type: research
Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1
Cancer stem cells (CSCs) are a small subset of malignant cells, possessing stemness, with strong tumorigenic capability, conferring resistance to therapy and leading to the relapse of nasopharyngeal carcinoma (NPC). Our previous study suggested that cyclooxygenase-2 (COX-2) would be a novel target for the CSCs-like side population (SP) cells in NPC. In the present study, we further found that COX-2 maintained the stemness of NPC by enhancing the activity of mitochondrial dynamin-related protein 1 (Drp1), a mitochondrial fission mediator, by studying both sorted SP cells from NPC cell lines and gene expression analyses in N...
Source: Theranostics - September 12, 2017 Category: Molecular Biology Authors: Teng-Jian Zhou, Shi-Li Zhang, Cheng-Yong He, Qun-Ying Zhuang, Pei-Yu Han, Sheng-Wei Jiang, Huan Yao, Yi-Jun Huang, Wen-Hua Ling, Yu-Chun Lin, Zhong-Ning Lin Tags: Research Paper Source Type: research
Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas
We investigated a therapeutic strategy for recurrent malignant gliomas using mesenchymal stem cells (MSC), expressing cytosine deaminase (CD), and prodrug 5-Fluorocytosine (5-FC) as a more specific and less toxic option. MSCs are emerging as a novel cell therapeutic agent with a cancer-targeting property, and CD is considered a promising enzyme in cancer gene therapy which can convert non-toxic 5-FC to toxic 5-Fluorouracil (5-FU). Therefore, use of prodrug 5-FC can minimize normal cell toxicity. Analyses of microarrays revealed that targeting DNA damage and its repair is a selectable option for gliomas after the standard c...
Source: Theranostics - June 26, 2016 Category: Molecular Biology Authors: Taemoon Chung, Juri Na, Young-il Kim, Da-Young Chang, Young Il Kim, Hyeonjin Kim, Ho Eun Moon, Keon Wook Kang, Dong Soo Lee, June-Key Chung, Sung-Soo Kim, Haeyoung Suh-Kim, Sun Ha Paek, Hyewon Youn Tags: Research Paper Source Type: research
