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pH-responsive DNA nanomicelles for chemo-gene synergetic therapy of anaplastic large cell lymphoma
Conclusion: DNMs co-loaded with Dox and ALK-specific siRNA exhibited significantly enhanced apoptosis of ALCL K299 cells in vitro and effectively inhibited tumor growth in vivo without obvious toxicity, providing a potential strategy in the development of nanomedicines for synergetic cancer therapy.
Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Yuwei Li, Shuzhen Yue, Jingyu Cao, Chengzhan Zhu, Yixiu Wang, Xin Hai, Weiling Song, Sai Bi Tags: Research Paper Source Type: research

Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and in vitro imaging applications
Conclusion: Based on these findings, we conclude that our newly synthesized NPCDs induced cell cycle arrest, autophagy, and apoptosis in B16F10 melanoma cells and presented good cellular bioimaging capability.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Vivek K. Bajpai, Imran Khan, Shruti Shukla, Sung-Min Kang, Faisal Aziz, Kumud Malika Tripathi, Deepika Saini, Hye-Jin Cho, Nam Su Heo, Sumit K. Sonkar, Lei Chen, Yun Suk Huh, Young-Kyu Han Tags: Research Paper Source Type: research

Chemotherapy priming of the Pancreatic Tumor Microenvironment Promotes Delivery and Anti-Metastasis Efficacy of Intravenous Low-Molecular-Weight Heparin-Coated Lipid-siRNA Complex
Conclusion: These results suggested our sequential delivery of PTX-Lip and LH-Lip/siBCL-2 might provide a practical approach for PDAC or other ECM-rich tumors.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Qianwen Yu, Yue Qiu, Xiaoxiao Chen, Xuhui Wang, Ling Mei, Haiyao Wu, Kai Liu, Yayuan Liu, Man Li, Zhirong Zhang, Qin He Tags: Research Paper Source Type: research