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Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia Research Communication
We studied the role of matrix metalloproteinase-10 (MMP-10) during skeletal muscle repair after ischemia using a model of femoral artery excision in wild-type (WT) and MMP-10 deficient (Mmp10–/–) mice. Functional changes were analyzed by small animal positron emission tomography and tissue morphology by immunohistochemistry. Gene expression and protein analysis were used to study the molecular mechanisms governed by MMP-10 in hypoxia. Early after ischemia, MMP-10 deficiency resulted in delayed tissue reperfusion (10%, P < 0.01) and in increased necrosis (2-fold, P < 0.01), neutrophil (4-fold, P < 0.01)...
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Gomez-Rodriguez, V., Orbe, J., Martinez-Aguilar, E., Rodriguez, J. A., Fernandez-Alonso, L., Serneels, J., Bobadilla, M., Perez-Ruiz, A., Collantes, M., Mazzone, M., Paramo, J. A., Roncal, C. Tags: Research Communication Source Type: research