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{mu}-Crystallin controls muscle function through thyroid hormone action Research Communication
In this study, Crym was preferentially expressed in skeletal muscle throughout the body. Crym-knockout mice exhibited a significant hypertrophy of fast-twitch glycolytic type IIb fibers, causing an increase in grip strength and high intensity running ability in Crym-null mice. Genetic inactivation of Crym or blockade of Crym by siRNA-mediated knockdown up-regulated the gene expression of fast-glycolytic contractile fibers in satellite cell-derived myotubes in vitro. These alterations in Crym-inactivated muscle were rescued by inhibition of thyroid hormone, even though Crym is a positive regulator of thyroid hormone action ...
Source: FASEB Journal - April 28, 2016 Category: Biology Authors: Seko, D., Ogawa, S., Li, T.-S., Taimura, A., Ono, Y. Tags: Research Communication Source Type: research