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Source: FASEB Journal
Cancer: Skin Cancer
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Total 1 results found since Jan 2013.
Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKC{alpha}-p38-SP-1 pathway Research Communications
In conclusion, CD44/selectin binding signals ICAM-1 up-regulation on the EC surface through a PKCα–p38–SP-1 pathway, which further enhances melanoma cell adhesion to ECs during metastasis.—Zhang, P., Goodrich, C., Fu, C., Dong, C. Melanoma upregulates ICAM-1 expression on ECs through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCα–p38–SP-1 pathway.
Source: FASEB Journal - October 30, 2014 Category: Biology Authors: Zhang, P., Goodrich, C., Fu, C., Dong, C. Tags: Research Communications Source Type: research
