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Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation
This report suggests asprosin as a novel therapeutic target for the treatment of type 2 diabetes through preservation of β-cell function.Graphical abstract
Source: Molecular and Cellular Endocrinology - March 8, 2019 Category: Endocrinology Source Type: research

Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
Publication date: Available online 6 April 2018Source: Molecular and Cellular EndocrinologyAuthor(s): L. Shcherbina, A. Lindqvist, A.-H. Thorén Fischer, E. Ahlqvist, E. Zhang, S.E. Falkmer, E. Renström, J. Koffert, H. Honka, N. WierupAbstractImpaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression.CART expression was foun...
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research

Endoplasmic reticulum stress regulates inflammation and insulin resistance in skeletal muscle from pregnant women
Publication date: 15 April 2016 Source:Molecular and Cellular Endocrinology, Volume 425 Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s were up...
Source: Molecular and Cellular Endocrinology - March 3, 2016 Category: Endocrinology Source Type: research

Endoplasmic reticulum stress regulates inflammation and insulin resistance in pregnant skeletal muscle
Publication date: Available online 20 February 2016 Source:Molecular and Cellular Endocrinology Author(s): Stella Liong, Martha Lappas Sterile inflammation and infection are key mediators of inflammation and peripheral insulin resistance associated with gestational diabetes mellitus (GDM). Studies have shown endoplasmic reticulum (ER) stress to induce inflammation and insulin resistance associated with obesity and type 2 diabetes, however is paucity of studies investigating the effects of ER stress in skeletal muscle on inflammation and insulin resistance associated with GDM. ER stress proteins IRE1α, GRP78 and XBP-1s...
Source: Molecular and Cellular Endocrinology - February 20, 2016 Category: Endocrinology Source Type: research

Fatty Acid-Binding Protein 4 mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy
Publication date: 15 August 2015 Source:Molecular and Cellular Endocrinology, Volume 411 Author(s): Fang Yao , Zhen Li , Takashi Ehara , Lin Yang , Dandan Wang , Lulu Feng , Yiming Zhang , Kun Wang , Yonghong Shi , Huijun Duan , Lianshan Zhang Type 2 diabetes is characterized by hyperglycemia and deregulated lipid metabolism with increased plasma non-esterified fatty acids (NEFA). Apoptosis of glomerular cells is a hallmark in diabetic glomerulosclerosis. Fatty acid-binding protein 4 (FABP4), a carrier protein for fatty acids, has been linked to diabetes and diabetic nephropathy (DN). Here we aimed to investigate the lin...
Source: Molecular and Cellular Endocrinology - June 26, 2015 Category: Endocrinology Source Type: research

Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway
In conclusion, DHM improved SMIR by inducing autophagy via the activation of AMPK signaling pathway.
Source: Molecular and Cellular Endocrinology - March 20, 2015 Category: Endocrinology Source Type: research

Inhibition of prolyl hydroxylase 3 ameliorates cardiac dysfunction in diabetic cardiomyopathy
Publication date: 5 March 2015 Source:Molecular and Cellular Endocrinology, Volume 403 Author(s): Yanfei Xia , Luwei Gong , Hui Liu , Beibei Luo , Bo Li , Rui Li , Beibei Li , Mei Lv , Jinyu Pan , Fengshuang An Prolyl hydroxylase 3 (PHD3) is a member of the prolyl hydroxylases (PHDs) family and is induced by hypoxia. It plays a critical role in regulating the abundance of hypoxia-inducible factor (HIF). Its expression is increased in diabetic rat hearts; however, its role remains unclear. We investigated the potential role and mechanism of action of PHD3 in the setting of diabetes-induced myocardial dysfunction in rats. ...
Source: Molecular and Cellular Endocrinology - January 27, 2015 Category: Endocrinology Source Type: research