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Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle
Publication date: Available online 29 October 2015 Source:Cell Reports Author(s): Anne Bigot, William J. Duddy, Zamalou G. Ouandaogo, Elisa Negroni, Virginie Mariot, Svetlana Ghimbovschi, Brennan Harmon, Aurore Wielgosik, Camille Loiseau, Joe Devaney, Julie Dumonceaux, Gillian Butler-Browne, Vincent Mouly, Stéphanie Duguez The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging. Here, using human cells and by carrying out experiments within a strictly pre-senescent divi...
Source: Cell Reports - October 31, 2015 Category: Cytology Source Type: research

Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes
Publication date: Available online 10 September 2015 Source:Cell Reports Author(s): Desy S. Lee, Jyh-Hong Chen, David J. Lundy, Chung-Hung Liu, Shiaw-Min Hwang, Lil Pabon, Ru-Chi Shieh, Chien-Chang Chen, Sheng-Nan Wu, Yu-Ting Yan, Sho-Tone Lee, Po-Min Chiang, Shu Chien, Charles E. Murry, Patrick C.H. Hsieh Pluripotent-cell-derived cardiomyocytes have great potential for use in research and medicine, but limitations in their maturity currently constrain their usefulness. Here, we report a method for improving features of maturation in murine and human embryonic-stem-cell-derived cardiomyocytes (m/hESC-C...
Source: Cell Reports - September 11, 2015 Category: Cytology Source Type: research