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Source: Cell Reports
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The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability
Publication date: Available online 14 April 2016 Source:Cell Reports Author(s): Teresa L.F. Ho, Guillaume Guilbaud, J. Julian Blow, Julian E. Sale, Christine J. Watson Regulation of DNA replication and cell division is essential for tissue growth and maintenance of genomic integrity and is particularly important in tissues that undergo continuous regeneration such as mammary glands. We have previously shown that disruption of the KRAB-domain zinc finger protein Roma/Zfp157 results in hyperproliferation of mammary epithelial cells (MECs) during pregnancy. Here, we delineate the mechanism by which Roma engenders th...
Source: Cell Reports - April 14, 2016 Category: Cytology Source Type: research
