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Source: Cell Reports
Condition: Staphylococcus Aureus
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S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking
Publication date: 27 February 2018 Source:Cell Reports, Volume 22, Issue 9 Author(s): Taylor S. Cohen, Michelle L. Boland, Brandon B. Boland, Virginia Takahashi, Andrey Tovchigrechko, Young Lee, Aimee D. Wilde, Mark J. Mazaitis, Omari Jones-Nelson, Christine Tkaczyk, Rajiv Raja, C. Kendall Stover, Bret R. Sellman Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tested the hypothesis that this protection is not due to a reduction in inf...
Source: Cell Reports - February 27, 2018 Category: Cytology Source Type: research
