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Source: Cell Reports
Cancer: Brain Cancers

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Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis
Publication date: 13 August 2019Source: Cell Reports, Volume 28, Issue 7Author(s): Hila Doron, Malak Amer, Nour Ershaid, Raquel Blazquez, Ophir Shani, Tzlil Gener Lahav, Noam Cohen, Omer Adler, Zahi Hakim, Sabina Pozzi, Anna Scomparin, Jonathan Cohen, Muhammad Yassin, Lea Monteran, Rachel Grossman, Galia Tsarfaty, Chen Luxenburg, Ronit Satchi-Fainaro, Tobias Pukrop, Neta ErezSummaryMelanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis is of great clinical importance. We used a mouse model of spont...
Source: Cell Reports - August 14, 2019 Category: Cytology Source Type: research