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Source: Journal of Neurochemistry
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Total 59 results found since Jan 2013.
Donepezil ‐induced oligodendrocyte differentiation is mediated through estrogen receptors
In conclusion, we demonstrated, for the first time, that donepezil‐induced oligodendrogenesis is mediated through both ER subtypes, ERα and ERβ.
Source: Journal of Neurochemistry - November 27, 2019 Category: Neuroscience Authors: Osamu Imamura,
Masaaki Arai,
Minori Dateki,
Kazuhiko Oishi,
Kunio Takishima Tags: ORIGINAL ARTICLE Source Type: research
Issue Cover (December 2019)
In conclusion, it reveals that PPARγ participates in the acquisition of neuron ischemic tolerance induced by IPC via regulating GLT‐1.Image content: The image is a representative photograph of thionin staining showing the histological change in CA1 hippocampus at 7d after brain ischemic insult. This image shows that ischemic insult, global brain ischemia for 8min, led to obvious neuronal death, which appeared neuronal pyknosis in CA1 hippocampus.Read the full preface‘Peroxisome proliferator‐activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via gl...
Source: Journal of Neurochemistry - November 23, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research
TGF ‐β1 activates RSC96 Schwann cells migration and invasion through MMP‐2 and MMP‐9 activities
AbstractFollowing peripheral nerve injury, remnant Schwann cells adopt a migratory phenotype and remodel the extracellular matrix allowing axonal regrowth. Although much evidence has demonstrated that TGF ‐β1 promotes glioma cell motility and induces the expression of extracellular matrix proteins, the effects of TGF‐β1 on Schwann cell migration has not yet been studied. We therefore investigated the cellular effects and the signal transduction pathways evoked by TGF‐β1 inrattus norvegicus neuronal Schwann RSC96 cell. TGF ‐β1 significantly increased migration and invasion of Schwann cells assessed by wound‐he...
Source: Journal of Neurochemistry - November 14, 2019 Category: Neuroscience Authors: Antonella Muscella,
Carla Vetrugno,
Luca Giulio Cossa,
Santo Marsigliante Tags: Original Article Source Type: research
Pro ‐inflammatory role of high‐mobility group box‐1 on brain mast cells via the RAGE/NF‐κB pathway
In this study, we used P815 cells to study the activating role of HMGB‐1 on MCs and to explore its potential mechanismin vitro. In anin vivo study, adult male Sprague ‐Dawley rats receivedi.c.v. injection of sterile saline or cromoglycate (stabilizer of MCs) 30 min prior toi.p. injection of HMGB ‐1. Increased levels of tumor necrosis factor and IL‐1β were observed in the P815 cells, as well as in the rats’ brains, after HMGB‐1 treatment. Pretreatment with the receptor of advanced glycation endproducts (RAGE)‐siRNA inhibited the HMGB‐1‐induced inflammatory process in the P815 cells. Activation of the RA...
Source: Journal of Neurochemistry - October 26, 2019 Category: Neuroscience Authors: Qing ‐Qing Qian,
Xiang Zhang,
Yi‐Wei Wang,
Jia‐Wen Xu,
Hong‐Quan Dong,
Na‐Na Li,
Yan‐Ning Qian,
Bo Gui Tags: Original Article Source Type: research
A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue Plasminogen Activator
AbstractPrion protein (PrPC) localizes stably in lipid rafts microdomains and is able to recruit downstream signal transduction pathways by the interaction with promiscuous partners. Other proteins have the ability to occasionally be recruited to these specialized membrane areas, within multimolecular complexes. Among these, we highlight the presence of the low ‐density lipoprotein receptor related protein 1 (LRP1), which was found localize transiently in lipid rafts, suggesting a different function of this receptor that through lipid raft becomes able to activate a signal transduction pathway triggered by specific ligan...
Source: Journal of Neurochemistry - October 10, 2019 Category: Neuroscience Authors: Vincenzo Mattei,
Valeria Manganelli,
Stefano Martellucci,
Antonella Capozzi,
Elisabetta Mantuano,
Agostina Longo,
Alberto Ferri,
Tina Garofalo,
Maurizio Sorice,
Roberta Misasi Tags: ORIGINAL ARTICLE Source Type: research
Cystatin C Improves Blood ‐Brain Barrier Integrity After Ischemic Brain Injury in Mice
AbstractCystatin C, a well ‐established biomarker of renal function, has been associated with a protective effect against stroke. However, the potential neuroprotective mechanism of cystatin C in ischemic brain injury remains unclear. Our study hypothesized that cystatin C can ameliorate blood‐brain barrier (BBB) disrupti on by upregulating caveolin‐1 expression, thereby improving neurological outcomes in cerebral ischemic injury. Western blotting, immunohistochemistry, immunofluorescence staining, and immunoprecipitation were performed to investigate target proteins. Evans Blue and gelatin zymography were used to ex...
Source: Journal of Neurochemistry - October 10, 2019 Category: Neuroscience Authors: Bo Yang,
Junjie Xu,
Liuhui Chang,
Zhigang Miao,
Dara Heang,
Yuwei Pu,
Xun Zhou,
Lingwei Zhang,
Hong Xie Tags: ORIGINAL ARTICLE Source Type: research
Subcellular NAMPT ‐mediated NAD+ salvage pathways and their roles in bioenergetics and neuronal protection after ischemic injury
AbstractNAD+ is a cofactor required for glycolysis, tricarboxylic acid cycle and complex I enzymatic reaction. In mammalian cells, NAD+ is predominantly synthesized through the salvage pathway, where nicotinamide phosphoribosyltransferase (NAMPT) is the rate ‐limiting enzyme. Previously, we demonstrated that NAMPT exerts a neuroprotective effect in ischemia through the suppression of mitochondrial dysfunction. Mammalian cells maintain distinct NAD+ pools in the cytosol, mitochondria and nuclei. However, it is unknown whether mitochondria have an intact machinery for NAD+ salvage, and if so, whether it plays a dominant ro...
Source: Journal of Neurochemistry - September 24, 2019 Category: Neuroscience Authors: Xiaowan Wang,
Zhe Zhang,
Nannan Zhang,
Hailong Li,
Li Zhang,
Christopher P. Baines,
Shinghua Ding Tags: Original Article Source Type: research
Alpha synuclein deficiency increases CD4+ T ‐cells pro‐inflammatory profile in a Nurr1‐dependent manner
AbstractIt has been suggested that extracellular alpha synuclein ( αSyn) can mediate neuroinflammation in Parkinson's disease, and that αSyn affects B‐cell maturation. However, the function of αSyn in T cells is poorly understood. We hypothesized that αSyn can affect CD4+ T ‐cell proliferation and activity. We found that αSyn deficiency exacerbates disease progression in 8 weeks old C57BL6/J EAE‐induced mice, and that αSyn‐deficient CD4+ T cells have increased pro ‐inflammatory response to myelin antigen relative to wild‐type cells, as measured by cytokine secretion of interleukin IL‐17 and interferon g...
Source: Journal of Neurochemistry - September 13, 2019 Category: Neuroscience Authors: Dorit Trudler,
Hilit Levy ‐Barazany,
Yuval Nash,
Liron Samuel,
Ronit Sharon,
Dan Frenkel Tags: ORIGINAL ARTICLE Source Type: research
Proinflammatory role of high ‐mobility group box‐1 on brain mast cells via the RAGE/NF‐κB pathway
In this study, we used P815 cells to study the activating role of HMGB‐1 on MCs and to explore its potential mechanismin vitro In anin vivo study, adult male Sprague ‐Dawley rats receivedi.c.v injection of sterile saline or cromoglycate (stabilizer of MCs) 30 min prior toi.p injection of HMGB ‐1. Increased levels of TNF and IL‐1β were observed in the P815 cells, as well as in the rats’ brains, after HMGB‐1 treatment. Pretreatment with the receptor of advanced glycation endproducts (RAGE)‐siRNA inhibited the HMGB‐1‐induced inflammatory process in the P815 cells. Activation of the RAGE/nuclear factor‐κB...
Source: Journal of Neurochemistry - September 13, 2019 Category: Neuroscience Authors: Qing ‐Qing Qian,
Xiang Zhang,
Yi‐Wei Wang,
Jia‐Wen Xu,
Hong‐Quan Dong,
Na‐Na Li,
Yan‐Ning Qian,
Bo Gui Tags: Original Article Source Type: research
Peroxisome proliferator ‐activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro
In conclusion, PPARγ participates in regulating GLT‐1 during the acquisition of BIT induced by IPC.Open science badgesThis article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/.Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/
Source: Journal of Neurochemistry - August 26, 2019 Category: Neuroscience Authors: Cong ‐Cong Zhao,
Meng‐Yang Jiang,
Ling‐Yan Zhang,
Yu‐Yan Hu,
Zhen‐Jie Hu,
Meng‐Yue Zhang,
Jie Qi,
A‐Chou Su,
Nan Lou,
Xiao‐Hui Xian,
Jing‐Ge Zhang,
Wen‐Bin Li,
Min Zhang Tags: Original Article Source Type: research
PPAR γ participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via GLT‐1 in vivo and in vitro
In conclusion, PPARγ participates in regulating GLT‐1 during the acquisition of BIT induced by IPC.This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - July 16, 2019 Category: Neuroscience Authors: Cong ‐Cong Zhao,
Meng‐Yang Jiang,
Ling‐Yan Zhang,
Yu‐Yan Hu,
Zhen‐Jie Hu,
Meng‐Yue Zhang,
Jie Qi,
A‐Chou Su,
Nan Lou,
Xiao‐Hui Xian,
Jing‐Ge Zhang,
Wen‐Bin Li,
Min Zhang Tags: Original Article Source Type: research
Nicotinamide phosphoribosyltransferase secreted from microglia via exosome during ischemic injury
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - July 2, 2019 Category: Neuroscience Authors: Yun ‐Bi Lu,
Chen‐Xiang Chen,
Jing Huang,
Yu‐Xin Tian,
Xian Xie,
Ping Yang,
Ming Wu,
Chun Tang,
Wei‐Ping Zhang Tags: Original Article Source Type: research
Neuronal Ca2+ ‐dependent activator protein 1 (NCDAP1) induces neuronal cell death by activating p53 pathway following traumatic brain injury
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - June 24, 2019 Category: Neuroscience Authors: Masaaki Arai,
Osamu Imamura,
Nobuo Kondoh,
Minori Dateki,
Kunio Takishima Tags: Original Article Source Type: research
Amyloid beta25 ‐35 impairs docosahexaenoic acid efflux by down‐regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - May 14, 2019 Category: Neuroscience Authors: Yusuke Ochiai,
Yasuo Uchida,
Masanori Tachikawa,
Pierre ‐Olivier Couraud,
Tetsuya Terasaki Tags: Original Article Source Type: research
Quantitative interaction proteomics reveals differences in the interactomes of amyloid precursor protein isoforms
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 21, 2019 Category: Neuroscience Authors: Robert J. Andrew,
Kate Fisher,
Kate J. Heesom,
Katherine A. B. Kellett,
Nigel M. Hooper Tags: Original Article Source Type: research
