• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Spinal Nrf2 translocation may inhibit neuronal NF ‐κB activation and alleviate allodynia in a rat model of bone cancer pain
This study aimed to test the hypothesis that BCP induces the transfer of Nrf2 from the cytoplasm to the nucleus and further promotes nuclear transcription to activate heme oxygenase-1 (HO-1) and inhibit the activation of nuclear factor-kappa B (NF- κB) signalling, ultimately regulating the neuroinflammatory response. Von-Frey was used for behavioural analysis in BCP rats, while western blotting, real-time quantitative PCR (RT-PCR), and enzyme-linked immunosorbent assay (ELISA) were used to detect molecular expression changes, and immunofluore scence was used to detect cellular localization. We demonstrated that BCP induce...
Source: Journal of Neurochemistry - July 14, 2021 Category: Neuroscience Authors: Jie Fu, Chaobo Ni, Hua ‐Dong Ni, Long‐Sheng Xu, Qiu‐Li He, Huan Pan, Dong‐Dong Huang, Yan‐Bao Sun, Ge Luo, Ming‐Juan Liu, Ming Yao Tags: ORIGINAL ARTICLE Source Type: research