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c-Abl Tyrosine Kinase-Mediated Neuronal Apoptosis in Subarachnoid Hemorrhage by Modulating the LRP-1-Dependent Akt/GSK3 β Survival Pathway
AbstractAccumulating evidence suggests that neuronal apoptosis plays a critical role in early brain injury (EBI) after subarachnoid hemorrhage (SAH), and the inhibition of apoptosis can induce neuroprotective effects in SAH animal models. c-Abl has been reported to promote neuronal apoptosis in Alzheimer ’s disease and cerebral ischemia, but its role in SAH had not been illuminated until now. In the present study, the effect of c-Abl on neuronal apoptosis induced by SAH was investigated. c-Abl protein levels and neuronal apoptosis were markedly increased 24 h after SAH, and the inhibition of endo genous c-Abl reduced ne...
Source: Journal of Molecular Neuroscience - November 22, 2021 Category: Neuroscience Source Type: research

Inhibition of BECN1 Suppresses Lipid Peroxidation by Increasing System X c − Activity in Early Brain Injury after Subarachnoid Hemorrhage
This study confirmed that SAH induced neurological deficits and brain edema, which was accompanied by the increase of BECN1 expression and lipid peroxidation, and the decrease of xCT expression and antioxidative capacity. However, downregulation of BECN1 by siRNA could decrease the formation of the BECN1 –xCT complex and lipid peroxidation, enhance antioxidative capacity, and ameliorate neurological deficits and brain edema in SAH rats. The results suggested that inhibition of BECN1 suppresses accumulation of lipid peroxidation by increasing system Xc− activity in EBI after SAH, and BECN1 may be a new effective target ...
Source: Journal of Molecular Neuroscience - February 4, 2019 Category: Neuroscience Source Type: research