Filtered By:
Source: Clinical Cancer Research
Condition: Translocation
This page shows you your search results in order of date.
Order by Relevance | Date
Total 2 results found since Jan 2013.
Nuclear FGFR1 regulates gene transcription and promotes antiestrogen resistance in ER+ breast cancer
CONCLUSIONS: These data suggest nuclear FGFR1 contributes to endocrine resistance by modulating gene transcription in ER+ breast cancer. Nuclear FGFR1 activity was unaffected by FGFR TKIs, thus supporting the development of treatment strategies to inhibit nuclear FGFR1 in ER+/FGFR1 overexpressing breast cancer.PMID:34011560 | DOI:10.1158/1078-0432.CCR-20-3905
Source: Clinical Cancer Research - May 20, 2021 Category: Cancer & Oncology Authors: Alberto Servetto Rahul Kollipara Luigi Formisano Chang-Ching Lin Kyung-Min Lee Dhivya R Sudhan Paula I Gonzalez-Ericsson Sumanta Chatterjee Angel Guerrero-Zotano Saurabh Mendiratta Hiroaki Akamatsu Nicholas James Roberto Bianco Ariella B Hanker Ralf Kittl Source Type: research
The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-κB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells.
CONCLUSIONS: MLN4924 disrupts NF-κB activation and induces Bim expression in CLL cells, thereby preventing stroma-mediated resistance. Our data provide rationale for further evaluation of MLN4924 in CLL. Clin Cancer Res; 20(6); 1576-89. ©2014 AACR.
PMID: 24634471 [PubMed - in process]
Source: Clinical Cancer Research - March 15, 2014 Category: Cancer & Oncology Authors: Godbersen JC, Humphries LA, Danilova OV, Kebbekus PE, Brown JR, Eastman A, Danilov AV Tags: Clin Cancer Res Source Type: research
