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Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma.
CONCLUSION: This study shows a novel connection between YAP-1 and the UPR through the c-Myc pathway during oxidative stress in HCC. The ROS-induced activation of YAP-1 via the c-Myc pathway, which leads to the activation of the UPR pathway, might be a therapeutic target in HCC. PMID: 33268949 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 14, 2020 Category: Gastroenterology Authors: Cho Y, Park MJ, Kim K, Kim SW, Kim W, Oh S, Lee JH Tags: World J Gastroenterol Source Type: research

Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and HepG2 hepatoma cells.
CONCLUSION: Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1. PMID: 28974890 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 14, 2017 Category: Gastroenterology Authors: Lu CJ, He YF, Yuan WZ, Xiang LJ, Zhang J, Liang YR, Duan J, He YH, Li MY Tags: World J Gastroenterol Source Type: research

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.
CONCLUSION: These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis. PMID: 28246472 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 13, 2017 Category: Gastroenterology Authors: Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP Tags: World J Gastroenterol Source Type: research

Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression.
CONCLUSION: Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression and might act as an anti-cancer therapeutic target in the future. PMID: 28018113 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 6, 2016 Category: Gastroenterology Authors: Su JR, Kuai JH, Li YQ Tags: World J Gastroenterol Source Type: research

Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the 5(th) most common malignancy which is responsible for more than half million annual mortalities; also, it is the third leading cause of cancer related death. Unfavorable systemic side-effects of chemotherapeutic agents and susceptibility to the degradation of small interfering RNAs (siRNAs), which can knock down a specific gene involved in the disease, have hampered their clinical application. So, it could be beneficial to develop an efficient carrier for the stabilization and specific delivery of drugs and siRNA to cells. Targeted nanoparticles have gained considerab...
Source: World Journal of Gastroenterology : WJG - November 14, 2015 Category: Gastroenterology Authors: Varshosaz J, Farzan M Tags: World J Gastroenterol Source Type: research

Effect of fibulin-5 on adhesion, migration and invasion of hepatocellular carcinoma cells via an integrin-dependent mechanism.
CONCLUSION: These results suggest that lower FBLN-5 expression is an important indicator of poor survival and that FBLN-5 inhibits HCC motility via an integrin-dependent mechanism. RGD-dependent suppression of MMP-7 by FBLN-5 might contribute to the development of new therapeutic strategies for HCC. PMID: 26494967 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 21, 2015 Category: Gastroenterology Authors: Tang JC, Liu JH, Liu XL, Liang X, Cai XJ Tags: World J Gastroenterol Source Type: research

Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells.
CONCLUSION: Down-regulation of Notch1 by GSI-I or siRNA combined with IL-24 can sensitize apoptosis and decrease the invasion and migration capabilities of HepG2 cells. PMID: 26361419 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 7, 2015 Category: Gastroenterology Authors: Han B, Liu SH, Guo WD, Zhang B, Wang JP, Cao YK, Liu J Tags: World J Gastroenterol Source Type: research

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease. In the last year, short double stranded RNA molecules termed small interfering RNAs (siRNAs) and micro interfering RNAs (miRNA), emerged as interesting molecules with potential therapeutic value for HCC. The practical use of these molecules is however limited by the identification of optimal molecular targets and especially by the lack of effec...
Source: World Journal of Gastroenterology : WJG - August 14, 2015 Category: Gastroenterology Authors: Farra R, Grassi M, Grassi G, Dapas B Tags: World J Gastroenterol Source Type: research

Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma.
CONCLUSION: Our data indicate that STAT4 may inhibit HCC development by modulating HCC cell proliferation. PMID: 25852285 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 7, 2015 Category: Gastroenterology Authors: Wang G, Chen JH, Qiang Y, Wang DZ, Chen Z Tags: World J Gastroenterol Source Type: research

Inhibition of autophagy significantly enhances combination therapy with sorafenib and HDAC inhibitors for human hepatoma cells.
CONCLUSION: HDACIs can sensitize HCC cells to sorafenib treatment by regulating the acetylation level of Beclin-1. PMID: 24833845 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 7, 2014 Category: Gastroenterology Authors: Yuan H, Li AJ, Ma SL, Cui LJ, Wu B, Yin L, Wu MC Tags: World J Gastroenterol Source Type: research

Interference of suppressor of cytokine signaling 3 promotes epithelial-mesenchymal transition in MHCC97H cells.
CONCLUSION: SOCS3 silencing is able to promote EMT in MHCC97H cells via changing the phenotypic characteristics and modulating the characteristic markers. PMID: 23430705 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 14, 2013 Category: Gastroenterology Authors: Ji YY, Wang ZD, Li ZF, Li K Tags: World J Gastroenterol Source Type: research