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Comparison of Nanocomplexes with Branched and Linear Peptides for SiRNA Delivery.
Abstract Efficient delivery of siRNA remains the greatest technological barrier to the clinical implementation of RNA interference strategies. We are investigating the relationship between the biophysical properties of siRNA nanocomplexes and their transfection efficiency as an approach to the generation of improved formulations. Peptide based formulations are of great interest and so in this study we have compared nanocomplex formulations for siRNA delivery containing linear and branched oligolysine or oligoarginine peptides. Peptides were combined with cationic liposomes in siRNA formulations and compared for tr...
Source: Biomacromolecules - January 22, 2013 Category: Biochemistry Authors: Tagalakis AD, Saraiva L, McCarthy D, Gustafsson KT, Hart SL Tags: Biomacromolecules Source Type: research

Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo.
Abstract Efficient delivery of small interfering RNA (siRNA) is one of major challenges in the successful applications of siRNA in clinic. In the present study, we report a new acid-degradable poly(ketal amidoamine) (PKAA) as a siRNA carrier, which has high delivery efficiency and low cytotoxicity. PKAA was designed to have acid-cleavable ketal linkages in the backbone of cationic biodegradable poly(amidoamine). PKAA efficiently self-assembled with siRNA to form nanocomplexes with a diameter of 200 nm and slightly positive charges, which are stable under physiological conditions, but rapidly release siRNA at ac...
Source: Biomacromolecules - December 16, 2012 Category: Biochemistry Authors: Lim H, Noh J, Kim Y, Kim H, Kim J, Khang G, Lee D Tags: Biomacromolecules Source Type: research

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