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Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo.
Abstract Efficient delivery of small interfering RNA (siRNA) is one of major challenges in the successful applications of siRNA in clinic. In the present study, we report a new acid-degradable poly(ketal amidoamine) (PKAA) as a siRNA carrier, which has high delivery efficiency and low cytotoxicity. PKAA was designed to have acid-cleavable ketal linkages in the backbone of cationic biodegradable poly(amidoamine). PKAA efficiently self-assembled with siRNA to form nanocomplexes with a diameter of 200 nm and slightly positive charges, which are stable under physiological conditions, but rapidly release siRNA at ac...
Source: Biomacromolecules - December 16, 2012 Category: Biochemistry Authors: Lim H, Noh J, Kim Y, Kim H, Kim J, Khang G, Lee D Tags: Biomacromolecules Source Type: research