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RVG peptide-linked trimethylated chitosan for delivery of siRNA to the brain.
Abstract In this work, a peptide derived from the rabies virus glycoprotein (RVG) was linked to siRNA/trimethylated chitosan (TMC) complexes through bifunctional PEG for efficient brain-targeted delivery of siRNA. The physiochemical properties of the complexes, such as siRNA complexing ability, size and zeta potential, morphology, serum stability and cytotoxicity, were investigated prior to studying the cellular uptake, in vitro gene silencing efficiency and in vivo biodistribution. The RVG peptide-linked siRNA/TMC-PEG complexes showed increased serum stability, negligible cytotoxicity and higher cellular uptake t...
Source: Biomacromolecules - February 18, 2014 Category: Biochemistry Authors: Gao Y, Wang Z, Zhang J, Zhang Y, Huo H, Wang T, Jiang T, Wang S Tags: Biomacromolecules Source Type: research