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Source: Autophagy
Cancer: Cancer
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Total 34 results found since Jan 2013.
The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
Autophagy. 2023 Jul 7:1-19. doi: 10.1080/15548627.2023.2229656. Online ahead of print.ABSTRACTApoptosis is a tightly controlled cell death program executed by proteases, the so-called caspases. It plays an important role in tissue homeostasis and is often dysregulated in cancer. Here, we identified FYCO1, a protein that promotes microtubule plus end-directed transport of autophagic and endosomal vesicles as a molecular interaction partner of activated CASP8 (caspase 8). The absence of FYCO1 sensitized cells to basal and TNFSF10/TRAIL-induced apoptosis by receptor accumulation and stabilization of the Death Inducing Signali...
Source: Autophagy - July 7, 2023 Category: Cytology Authors: Valeria Coppola Ilaria Marino Uwe Warnken Mario Falchi Luca Pasquini Mauro Biffoni Ruggero De Maria Tobias Longin Haas Source Type: research
Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway
This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway. First, we found that MCOLN1-mediated autophagy inhibition not only profoundly inhibits both migration and invasion in malignant melanoma and glioma cell lines in vitro, but also suppresses melanoma metastasis in vivo. Second, our study reveals that autophagy inhibition induced by MCOLN1 leads to damaged mitochondria accumulation followed by large quantities of ROS release. Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP...
Source: Autophagy - December 8, 2021 Category: Cytology Authors: Yanhong Xing Xiangqing Wei Yucheng Liu Meng-Meng Wang Zhongheng Sui Xinyan Wang Wucheng Zhu Mengmei Wu Chen Lu Yuan-Hui Fei Yi Jiang Yang Zhang Yuqing Wang Feng Guo Jun-Li Cao Jiansong Qi Wuyang Wang Source Type: research
HYPK coordinates degradation of polyneddylated proteins by autophagy
Autophagy. 2021 Nov 26:1-22. doi: 10.1080/15548627.2021.1997053. Online ahead of print.ABSTRACTSelective degradation of protein aggregates by macroautophagy/autophagy is an essential homeostatic process of safeguarding cells from the effects of proteotoxicity. Among the ubiquitin-like proteins, NEDD8 conjugation to misfolded proteins is prominent in stress-induced protein aggregates, albeit the function of neddylation in autophagy is unclear. Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show that HYPK...
Source: Autophagy - November 27, 2021 Category: Cytology Authors: Debasish Kumar Ghosh Akash Ranjan Source Type: research
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells
In this study, we show that NDV infection reprograms cell metabolism by increasing glucose utilization in the glycolytic pathway. Mechanistically, NDV induces mitochondrial damage, elevated mitochondrial reactive oxygen species (mROS) and ETC dysfunction. Infection of cells depletes nucleotide triphosphate levels, resulting in elevated AMP:ATP ratios, AMP-activated protein kinase (AMPK) phosphorylation, and MTOR crosstalk mediated autophagy. In a time-dependent manner, NDV shifts the balance of mitochondrial dynamics from fusion to fission. Subsequently, PINK1-PRKN-dependent mitophagy was activated, forming a ubiquitin cha...
Source: Autophagy - November 1, 2021 Category: Cytology Authors: Yabin Gong Ning Tang Panrao Liu Yingjie Sun Shanxin Lu Weiwei Liu Lei Tan Cuiping Song Xusheng Qiu Ying Liao Shengqing Yu Xiufan Liu Shu-Hai Lin Chan Ding Source Type: research
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Autophagy. 2021 Sep 15:1-19. doi: 10.1080/15548627.2021.1965421. Online ahead of print.ABSTRACTEpidemiological and clinical studies have shown that exposure to particulate matter (PM) is associated with an increased incidence of lung cancer and metastasis. However, the underlying mechanism remains unclear. Here, we demonstrated the central role of PM-induced neutrophil recruitment in promoting lung cancer metastasis. We found that reactive oxygen species (ROS)-mediated alveolar epithelial macroautophagy/autophagy was essential for initiating neutrophil chemotaxis and pre-metastatic niche formation in the lungs in response ...
Source: Autophagy - September 15, 2021 Category: Cytology Authors: Jiajun Liu Shumin Li Xuefeng Fei Xi Nan Yingying Shen Huiqing Xiu Stephania A Cormier Chaojie Lu Chuqi Guo Shibo Wang Zhijian Cai Pingli Wang Source Type: research
