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Source: Annals of Clinical and Laboratory Science

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Total 257 results found since Jan 2013.

Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion.PMID:33334789
Source: Annals of Clinical and Laboratory Science - December 18, 2020 Category: Laboratory Medicine Authors: Zhengming Yang Jianjun Qian Wei Yu Minfei Yang Bin Liu Huimin Tao Source Type: research

Role of Estrogen Receptor-Mediated Anti-Tumor Effects in U2OS Cells.
CONCLUSIONS: 17β-estradiol exhibited significant anti-tumor effects on U2OS cells that were mediated by ERs and reduced cell proliferation, migration, and invasion. PMID: 33334789 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - November 1, 2020 Category: Laboratory Medicine Authors: Yang Z, Qian J, Yu W, Yang M, Liu B, Tao H Tags: Ann Clin Lab Sci Source Type: research

EZH2 Downregulation Augments the Effect of Irradiation in Reducing Pancreatic Cancer Cell Proliferation in vitro.
CONCLUSIONS: EZH2 downregulation in combination with irradiation reduces PANC-1 and MIA PaCa-2 cell proliferation more than irradiation alone. This study affirms the role of EZH2 downregulation for radiosensitization in pancreatic cancer treatment. PMID: 32161011 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - December 31, 2019 Category: Laboratory Medicine Authors: Agrawal R, Chen M, Bukhari Z, Ogunwobi OO, Haseeb MA, Martello LA Tags: Ann Clin Lab Sci Source Type: research

Effect of Pim-3 Downregulation on Proliferation and Apoptosis in Lung Adenocarcinoma A549 Cells.
CONCLUSION: The downregulation of Pim-3 was closely related to the activation status of the lung STAT3 signaling pathway, mediated cell proliferation inhibition and induced apoptosis. PMID: 31882428 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - October 31, 2019 Category: Laboratory Medicine Authors: Fan X, Xie Y, Zhang L, Gao X, Han J, Chen Y, Yang J, Li S Tags: Ann Clin Lab Sci Source Type: research

The Regulatory Effects of CDKN1A on Relevant Genes in Kaposi's Sarcoma Cells.
Abstract The cyclin-dependent kinase inhibitor 1A (CDKN1A) gene plays important roles in different types of cancer; however, its mechanism in Kaposi's Sarcoma (KS) is far less known. The aim of this study is to investigate the regulatory effects of CDKN1A on relevant genes in KS cells, and ultimately determine the role of CDKN1A in KS. In the study, the CDKN1A overexpression group, or siRNA group, was transfected into KS cells, respectively. Western-Blot (WB) and quantitative real-time polymerase chain reactions (q-PCR) were performed to detect the expression of cell cycle protein D1 (CyclinD1) and cell cycle prot...
Source: Annals of Clinical and Laboratory Science - August 31, 2019 Category: Laboratory Medicine Authors: Zhang J, Pu XM, Wu XJ Tags: Ann Clin Lab Sci Source Type: research

Sp-1 Negatively Regulates miR-20b Expression in Macrophages.
In this study, we are using the miRBase database to obtain the upstream 2000 bp sequence of the miR-20b precursor. Bio-informatics software P-MATCH 1.0 and AliBaba2 werethen used to predict transcription factor binding in the upstream region. Sp-1 was identified as one of the most probable transcription factors regulating miR-20b gene expression. After treatment with a Sp-1 siRNA, the expression of miR-20b was significantly increased in RAW264.7 cells, as well as peritoneal and alveolar macrophages. In addition, the interference with Sp-1 gene expression also reversed the decrease in miR-20b expression in RAW264.7 cells in...
Source: Annals of Clinical and Laboratory Science - November 1, 2017 Category: Laboratory Medicine Authors: Guo S, Wang H, Luo Y, He J, Ma H, Shen L, Tang J, Fang Q, Wang H, Qian Z, Song C Tags: Ann Clin Lab Sci Source Type: research

Overexpression of HHEX in Acute Myeloid Leukemia with t(8;21)(q22;q22) Translocation.
CONCLUSIONS: HHEX is expressed in multiple types of AML, with the highest levels seen in t(8;21) AML. HHEX was essential for Kasumi-1 cell proliferation and may represent a potential therapeutic target enabling against AML. PMID: 29263042 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - November 1, 2017 Category: Laboratory Medicine Authors: Zhang S, Ma L, Chen Y, Xu H, Chen S, Wu W Tags: Ann Clin Lab Sci Source Type: research

Aquaporin-4 Blockage by siRNA Protects Rat Articular Chondrocytes from IL-1 β-induced Apoptosis by Inhibiting p38 MAPK Signal Pathway.
Aquaporin-4 Blockage by siRNA Protects Rat Articular Chondrocytes from IL-1β-induced Apoptosis by Inhibiting p38 MAPK Signal Pathway. Ann Clin Lab Sci. 2017 Sep;47(5):563-571 Authors: Cai L, Lei C, Li R, Chen WN, Li CM Abstract Accumulating evidence reveals that articular chondrocytes undergo increased apoptosis in rheumatoid arthritis (RA) and inhibiting chondrocyte apoptosis might be a promising therapeutic strategy. We recently found that aquaporin-4 (AQP4) protein level in the cartilage of rats with adjuvant-induced arthritis was higher than normal rats. Herein, cultured rat articular chondrocyte...
Source: Annals of Clinical and Laboratory Science - September 1, 2017 Category: Laboratory Medicine Authors: Cai L, Lei C, Li R, Chen WN, Li CM Tags: Ann Clin Lab Sci Source Type: research

Downregulated Smad4 Affects Extracellular Matrix Remodeling in Ventilator-induced Lung Injury.
CONCLUSION: Smad4 gene silencing may be a therapeutic target for treating ventilator-induced lung injury and pulmonary fibrosis. PMID: 27650609 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - August 31, 2016 Category: Laboratory Medicine Authors: Huang X, Zhou W, Ding S Tags: Ann Clin Lab Sci Source Type: research

HIF-1α Silencing Inhibits the Growth of Osteosarcoma Cells by Inducing Apoptosis.
Abstract BACKGROUND: Osteosarcoma (OS) is a malignant tumor of mesenchymal origin, which is generally locally aggressive and tends to produce early systemic metastases. Therefore, an identification of a novel therapeutic target is required. METHODS: We investigated the effect of small interfering RNA (siRNA) targeting hypoxia-inducible factor 1α (HIF-1α) on the growth of Osteosarcoma MG-63 and U2-OS cells. Two cell-lines were transfected with various concentrations of HIF-1α or control siRNA, and the effect on HIF-1α expression was analyzed by using quantitative polymerase chain reaction and western blot ...
Source: Annals of Clinical and Laboratory Science - February 29, 2016 Category: Laboratory Medicine Authors: Lv F, Du R, Shang W, Suo S, Yu D, Zhang J Tags: Ann Clin Lab Sci Source Type: research

Effect of Small Interference RNA on the Acetylcholine-Sensitive Potassium Channel in H9c2 Cells.
CONCLUSION: siRNA could effectively inhibit the IK(ACh) channel and is a potential therapy for atrial fibrillation. PMID: 25696012 [PubMed - as supplied by publisher]
Source: Annals of Clinical and Laboratory Science - January 1, 2015 Category: Laboratory Medicine Authors: He F, Zhao J, Li L, Guo R Tags: Ann Clin Lab Sci Source Type: research