• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Targeted-gene silencing of BRAF to interrupt BRAF/MEK/ERK pathway synergized photothermal therapeutics for melanoma using a novel FA-GNR-siBRAF nanosystem
Melanoma is significantly associated with mutant BRAF gene, a suitable target for siRNA-based anti-melanoma therapy. However, a tumor-specific delivery system is a major hurdle for clinical applications. Here, we developed a novel nano-carrier, FA-GNR-siBRAF for safe topical application, which consists of folic acid (FA) as the tumor-targeting moiety, golden nanorods (GNR) providing photothermal capability to kill tumor cells under laser irradiation, and siRNA specifically silencing BRAF (siBRAF).
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - April 20, 2018 Category: Nanotechnology Authors: Yujuan Zhang, Xuelin Zhan, Shanshan Peng, Ying Cai, Yu Shrike Zhang, Yanling Liu, Zhigang Wang, Yanrong Yu, Yifan Wang, Qiaofa Shi, Xiaoping Zeng, Keng Yuan, Nanjin Zhou, Rakesh Joshi, Meng Zhang, Zhuxu Zhang, Weiping Min Source Type: research

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum
In this study the receptor specific uptake of folic acid-functionalized iron oxide nanoparticles was determined in ovarian cancer cells. It was found that the presence of serum proteins is an absolute requirement for the uptake of these nanoparticles. The described strategy for receptor-mediated uptake of nanoparticles with pre-defined surface chemistry may enable a better targeting of nanoparticles for additional therapeutic and imaging applications.Graphical Abstract: Targeted, i.e. receptor-mediated cellular uptake of folic acid (FA)-conjugated iron oxide nanoparticles is shown for particles with SiO2 coating, but not f...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - February 3, 2014 Category: Nanotechnology Authors: Annette Krais, Laura Wortmann, Laura Hermanns, Neus Feliu, Marie Vahter, Stefan Stucky, Sanjay Mathur, Bengt Fadeel Tags: Cell Biology, Cell Physiology, Receptor-Specific Uptake, Effect of Pegylation, Serum Proteins, FA-Iron Oxide NPs Source Type: research

A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer
Gemcitabine is currently the standard therapy for pancreatic cancer. However, growing concerns over gemcitabine resistance mean that new combinatory therapies are required to prevent loss of efficacy with prolonged treatment. Here, we suggest that this could be achieved through co-administration of RNA interference agents targeting the ubiquitin ligase ITCH. Stable anti-ITCH siRNA and shRNA dendriplexes with a desirable safety profile were prepared using generation 3 poly(propylenimine) dendrimers (DAB-Am16).
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - September 26, 2014 Category: Nanotechnology Authors: Maria de la Fuente, Marie-Christine Jones, Manuel J. Santander-Ortega, Anja Mirenska, Preethi Marimuthu, Ijeoma Uchegbu, Andreas Schätzlein Source Type: research

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and Gene Suppression
This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based nanoplatforms for cancer-targeted delivery of near-infrared photosensitizer, phthalocyanine, and DJ-1 siRNA have been constructed. In vitro studies revealed that therapeutic efficacy of the combinatorial approach was enhanced when compared to PDT alone and this enhancement was more pronounced in o...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - July 31, 2015 Category: Nanotechnology Authors: Canan Schumann, Olena Taratula, Oleh Khalimonchuk, Amy L. Palmer, Lauren M. Cronk, Carson V. Jones, Cesar A. Escalante, Oleh Taratula Source Type: research

Single-Step Microfluidic Synthesis of Transferrin-Conjugated Lipid Nanoparticles for siRNA Delivery
In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs) and the method was compared with a multi-steps bulk mixing (BM) method. The results indicate that this single-step MF process enables rapid and efficient synthesis of Tf-LNPs, which were named Tf-LNPs-MF.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - October 5, 2016 Category: Nanotechnology Authors: Yujing Li, Robert J. Lee, Xueqin Huang, Yuhuan Li, Bingcong Lv, Tianpeng Wang, Yuhang Qi, Fei Hao, Jiahui Lu, Qingfan Meng, Lirong Teng, Yulin Zhou, Jing Xie, Lesheng Teng Source Type: research

Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA
Lipid nanoparticles (LNPs) containing distearolyphosphatidlycholine (DSPC), and ionizable amino-lipids such as (6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. Here we explore the utility of similar LNP systems as transfection reagents for plasmid DNA (pDNA). It is shown that replacement of DSPC by unsaturated PCs and DLin-MC3-DMA by the related lipid DLin-KC2-DMA resulted in highly potent transfection reagents for HeLa cells in vitro.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - December 26, 2016 Category: Nanotechnology Authors: Jayesh A. Kulkarni, J. Layne Myhre, Sam Chen, Yuen Yi C. Tam, Adrian Danescu, Joy M. Richman, Pieter R. Cullis Source Type: research

Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer
TWIST protein is critical to development and is activated in many cancers. TWIST regulates epithelial-mesenchymal transition, and is linked to angiogenesis, metastasis, cancer stem cell phenotype, and drug resistance. The majority of epithelial ovarian cancer (EOC) patients with metastatic disease respond well to first-line chemotherapy but most relapse with disease that is both metastatic and drug resistant, leading to a five-year survival rate under 20%. We are investigating the role of TWIST in mediating these relapses.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - April 14, 2018 Category: Nanotechnology Authors: Sophia A. Shahin, Ruining Wang, Shirleen I. Simargi, Altagracia Contreras, Liliana Parra, Louise Qu, Wei Wen, Thanh Dellinger, Juli Unternaehrer, Fuyuhiko Tamanoi, Jeffrey I. Zink, Carlotta A. Glackin Tags: Original Article Source Type: research

Pulmonary delivery of polyplexes for combined PAI-1 gene silencing and CXCR4 inhibition to treat lung fibrosis
This report describes the development of polyplexes based on CXCR4-inhibiting poly(ethylenimine) derivative (PEI-C) for pulmonary delivery of siRNA to silence plasminogen activator inhibitor-1 (siPAI-1) as a new combination treatment of pulmonary fibrosis (PF). Safety and delivery efficacy of the PEI-C/siPAI-1 polyplexes was investigated in vitro in primary lung fibroblasts isolated from mice with bleomycin-induced PF. Biodistribution analysis following intratracheal administration of fluorescently labeled polyplexes showed prolonged retention in the lungs.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - May 17, 2018 Category: Nanotechnology Authors: B.S. Ling Ding, B.S. Chenfei Zhu, M.S. Fei Yu, M.S. Pengkai Wu, M.S. Gang Chen, B.S. Aftab Ullah, Kaikai Wang, Minjie Sun, Jing Li, David Oupick ý Source Type: research

Pages: 1  2  3  4