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Source: Oncology Research
Drug: Insulin
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Total 1 results found since Jan 2013.
MicroRNA-664 targets Insulin receptor substrate 1 to suppress cell proliferation and invasion in breast cancer.
This study showed that miR-664 expression was obviously reduced in BC tissues and cell lines. Resumption expression of miR-664 attenuated the proliferation and invasion of BC cells. The molecular mechanism underlying the inhibitory effects of BC cell proliferation and invasion by miR-664 was also studied. Insulin receptor substrate 1 (IRS1) was identified as a novel and direct target of miR-664. In addition, siRNA-mediated silencing of IRS1 expression mimicked the suppressive effects of miR-664 overexpression in BC cells. Rescue experiments demonstrated that recovered IRS1 expression partially antagonized the inhibition of...
Source: Oncology Research - March 3, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research
