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The downregulation of miR-200c promotes lactate dehydrogenase A expression and non-small cell lung cancer progression.
This study was aimed to investigate the function and mechanism of microRNA-200c (miR-200c) in the progression of non-small cell lung cancer (NSCLC). A total of 76 patients diagnosed as NSCLC were enrolled in this study. Then, the expression level of miR-200c in NSCLC tissues and cell lines was investigated using the quantitative realtime polymerase chain reaction (RT-qPCR) method. We found the expression of miR200c was significantly reduced in NSCLC tissues and cell lines compared with in normal lung tissues and human bronchial epithelial cell line. Force the expression of miR-200c using miR-200c mimic significantly suppre...
Source: Oncology Research - January 14, 2018 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MiR-449a Suppresses LDHA-Mediated Glycolysis to Enhance the Sensitivity of Non-Small Cell Lung Cancer Cells to Ionizing Radiation.
Authors: Li L, Liu H, Du L, Xi P, Wang Q, Li Y, Liu D Abstract MicroRNA dysregulation contributes to malignant progression, dissemination and profound treatment resistance in multiple cancers. MiR-449a is recognized as a tumor suppresser. However, roles of miR-449a in lung cancers initiation and progression are largely unrevealed. Our study aims to investigate roles and the underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancers (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR, levels of target protein...
Source: Oncology Research - August 14, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

MicroRNA-138 Inhibits Cell Growth, Invasion, and EMT of Non-Small Cell Lung Cancer Via SOX4/p53 Feedback Loop.
In this study, we investigated the biological functions and molecular mechanisms of miR-138 in NSCLC cell lines, discussing whether it could be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-138 is down-regulated in NSCLC tissues and cell lines. Moreover, the low level of miR-138 was associated with increased expression of SOX4 in NSCLC tissues and cell lines. Up-regulation of miR-138 significantly inhibited proliferation of NSCLC cells. In addition, invasion and EMT of NSCLC cells was suppressed by overexpression of miR-138. However, down-regulation of miR-138 promoted cell growth and meta...
Source: Oncology Research - June 28, 2017 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

Knockdown of PFTK1 Expression by RNAi Inhibits the Proliferation and Invasion of Human Non-Small Lung Adenocarcinoma Cells.
In this study, we aimed to explore the expression and function of PFTK1 in NSCLC cells. Our results showed that PFTK1 was significantly upregulated in human NSCLC cell lines. Silencing the expression of PFTK1 inhibited the proliferation of NSCLC cells. In addition, silencing the expression of PFTK1 endowed NSCLC cells with decreased migration and invasion abilities, as well as epithelial-mesenchymal transition (EMT) progress in A549 cells. A mechanistic study showed that knockdown of PFTK1 inhibited the expression of β-catenin, cyclin D1, and c-Myc in A549 cells. In summary, we report that small interfering RNA (siRNA)-PF...
Source: Oncology Research - July 29, 2016 Category: Cancer & Oncology Tags: Oncol Res Source Type: research

FOXM1 Regulated by ERK Pathway MediatesTGF-β1-Induced EMT in NSCLC.
Authors: Kong FF, Zhu YL, Yuan HH, Wang JY, Zhao M, Gong XD, Liu F, Zhang WY, Wang CR, Jiang B Abstract FOXM1, a member of the Forkhead transcriptional family, plays an important role in the EMT process, and transforming growth factor-β1 (TGF-β1) has been identified as the most potent factor that can independently induce EMT in various types of cancer cells. Here we examine the important role of FOXM1 in TGF-β1-induced EMT and investigate the mechanism underlying the relationship between TGF-β1 and FOXM1. Lentivirus-mediated transfection was used to stably upregulate the expression of FOXM1, and a small interfe...
Source: Oncology Research - February 26, 2015 Category: Cancer & Oncology Tags: Oncol Res Source Type: research