Filtered By:
Source: Toxicology Letters
Condition: Brain Tumor
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 1 results found since Jan 2013.
Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells.
Abstract
N-cadherin has known to be involved in tumor progression and metastasis. However, it is still obscure about the signaling pathway involving in the processing of N-cadherin. Thus, we examined which signaling pathway plays a major role in the processing of N-cadherin in C6 glioma cells following treatment of Cadmium (Cd), a highly ubiquitous heavy metal. A cleavage product of N-cadherin, N-cad/CTF2 was observed by the treatment of Cd to C6 cells in a time and concentration-dependent manner. The production of N-cad/CTF2 was inhibited by pretreatment of γ-secretase inhibitors or siRNA transfection of nicastr...
Source: Toxicology Letters - July 19, 2013 Category: Toxicology Authors: Jo C, Koh YH Tags: Toxicol Lett Source Type: research
