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Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic
Toxicol Appl Pharmacol. 2021 Nov 16;434:115799. doi: 10.1016/j.taap.2021.115799. Online ahead of print.ABSTRACTArsenic is a naturally occurring element present in food, soil and water and human exposure is associated with increased cancer risk. Arsenic inhibits DNA repair at low, non-cytotoxic concentrations and amplifies the mutagenic and carcinogenic impact of other DNA-damaging agents, such as ultraviolet radiation (UVR). Arsenic exposure leads to oxidation of zinc coordinating cysteine residues, zinc loss and decreased activity of the DNA repair protein poly(ADP)ribose polymerase (PARP)-1. Because arsenic stimulates NA...
Source: Toxicology and Applied Pharmacology - November 19, 2021 Category: Toxicology Authors: Karen L Cooper Lindsay B Volk Dayna R Dominguez Antonia D Duran K J Ke Jian Liu Laurie G Hudson Source Type: research

Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer.
Abstract Cancer mortality is mainly caused by metastasis, which requires dynamic remodeling of cytoskeletal components such as microtubules. Targeting microtubules presents a promising antimetastatic strategy that could prevent cancer spreading and recurrence. It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). We found that cytoplasmic linker protein 170 (CLIP170) was overexpres...
Source: Toxicology and Applied Pharmacology - July 23, 2020 Category: Toxicology Authors: Gao L, Xue B, Xiang B, Liu KJ Tags: Toxicol Appl Pharmacol Source Type: research