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Enzyme-sensitive nanoparticles, smart TAT and cetuximab conjugated immunoliposomes to overcome multidrug resistance in breast cancer cells
Toxicol Appl Pharmacol. 2022 Mar 18:115989. doi: 10.1016/j.taap.2022.115989. Online ahead of print.ABSTRACTDue to recent advances in the field of small molecule-based drugs, designing an efficient siRNA delivery system seems essential. Here, modified sets of lipids conjugated with cell-penetrating TAT peptide, MMP2 enzyme-sensitive moiety, and cetuximab antibodies against the EGF receptor were synthesized, purified and verified on HPLC, TLC, SEM, and DLS analyses. Different cellular and molecular experiments were designed to evaluate the transfection efficiency, targeting properties, and functions, including cytotoxicity a...
Source: Toxicology and Applied Pharmacology - March 22, 2022 Category: Toxicology Authors: Mohsen Safaei Pegah Khosravian Sedighe Kazemi Sheykhshabani Gashtasb Mardani Fatemeh Elahian Seyed Abbas Mirzaei Source Type: research

The inhibitory and combinative mechanism of HZ08 with P-glycoprotein expressed on the membrane of Caco-2 cell line.
In conclusion, as a P-glycoprotein substrate, HZ08 inhibited P-glycoprotein activity and may share the same binding site of verapamil to P-glycoprotein. PMID: 24321342 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - December 6, 2013 Category: Toxicology Authors: Zhang Y, Hu Y, Feng Y, Darshika KN, Fang W, Li Y, Huang W Tags: Toxicol Appl Pharmacol Source Type: research