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Enzyme-sensitive nanoparticles, smart TAT and cetuximab conjugated immunoliposomes to overcome multidrug resistance in breast cancer cells
Toxicol Appl Pharmacol. 2022 Mar 18:115989. doi: 10.1016/j.taap.2022.115989. Online ahead of print.ABSTRACTDue to recent advances in the field of small molecule-based drugs, designing an efficient siRNA delivery system seems essential. Here, modified sets of lipids conjugated with cell-penetrating TAT peptide, MMP2 enzyme-sensitive moiety, and cetuximab antibodies against the EGF receptor were synthesized, purified and verified on HPLC, TLC, SEM, and DLS analyses. Different cellular and molecular experiments were designed to evaluate the transfection efficiency, targeting properties, and functions, including cytotoxicity a...
Source: Toxicology and Applied Pharmacology - March 22, 2022 Category: Toxicology Authors: Mohsen Safaei Pegah Khosravian Sedighe Kazemi Sheykhshabani Gashtasb Mardani Fatemeh Elahian Seyed Abbas Mirzaei Source Type: research

Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression
In this study, we established a Dox-induced cardiotoxicity model in H9c2 cardiomyocytes, zebrafish, and SD rats to explore the mechanism by which Mel alleviates Dox-induced cardiotoxicity. In vivo and in vitro experiments showed that Dox significantly decreased the viability of H9c2 cells, induced apoptosis, myocardial injury, and effectively up-regulated the expression of p-YAP but down-regulated the expression of YAP. Furthermore, we found that Dox significantly up-regulated the expression of ferroptosis-associated protein ACSL4 and down-regulated expression of GPX4. Interestingly, these effects of Dox were reversed foll...
Source: Toxicology and Applied Pharmacology - January 30, 2022 Category: Toxicology Authors: Xiao Sun Ping Sun Dong Zhen Xiangli Xu Li Yang Danni Fu Chengxi Wei Xiaofeng Niu Jiawei Tian Hairu Li Source Type: research

Involvement of m6A regulatory factor IGF2BP1 in malignant transformation of human bronchial epithelial Beas-2B cells induced by tobacco carcinogen NNK
This study therefore contributes novel insights into the environmental pathogenesis of lung cancer and the gene regulatory mechanisms of chemical carcinogenesis.PMID:34974052 | DOI:10.1016/j.taap.2021.115849
Source: Toxicology and Applied Pharmacology - January 2, 2022 Category: Toxicology Authors: Jiaxin Zhou Rui Xiong Jiazhen Zhou Xinchao Guan Guanqing Jiang Yuyang Chen Qiaoyuan Yang Source Type: research

Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic
Toxicol Appl Pharmacol. 2021 Nov 16;434:115799. doi: 10.1016/j.taap.2021.115799. Online ahead of print.ABSTRACTArsenic is a naturally occurring element present in food, soil and water and human exposure is associated with increased cancer risk. Arsenic inhibits DNA repair at low, non-cytotoxic concentrations and amplifies the mutagenic and carcinogenic impact of other DNA-damaging agents, such as ultraviolet radiation (UVR). Arsenic exposure leads to oxidation of zinc coordinating cysteine residues, zinc loss and decreased activity of the DNA repair protein poly(ADP)ribose polymerase (PARP)-1. Because arsenic stimulates NA...
Source: Toxicology and Applied Pharmacology - November 19, 2021 Category: Toxicology Authors: Karen L Cooper Lindsay B Volk Dayna R Dominguez Antonia D Duran K J Ke Jian Liu Laurie G Hudson Source Type: research

Nimbolide attenuated the inflammation in the liver of autoimmune hepatitis's mice through regulation of HDAC3
Toxicol Appl Pharmacol. 2021 Nov 12:115795. doi: 10.1016/j.taap.2021.115795. Online ahead of print.ABSTRACTA chronic liver disease named autoimmune hepatitis (AIH) will carry elevated levels of inflammatory cytokines, but there is currently no effective treatment to cure it. Histone deacetylase 3 (HDAC3) takes an important position in regulating the expression of inflammatory genes. Nimbolide (NIB) is a limonoid extracted from the neem tree (Azadirachta indica) that has been found to be effective against many diseases, including cancer, scleroderma, and acute respiratory distress syndrome. Here, we investigated the protect...
Source: Toxicology and Applied Pharmacology - November 15, 2021 Category: Toxicology Authors: Dingchao Xia Dazhi Chen Tingchen Cai Lujian Zhu Yanhan Lin Sijie Yu Kailu Zhu Xiaodong Wang Lanman Xu Yongping Chen Source Type: research

MST2 silencing induces apoptosis and inhibits tumor growth for estrogen receptor alpha-positive MCF-7 breast cancer.
Abstract Mammalian sterile 20-like kinase 1/2 (MST1/2) plays an important role in cell growth and apoptosis and functions as a tumor suppressor. Previously, we showed that MST2 overexpression activates Estrogen receptor alpha (ERα) in human breast cancer MCF-7 cells in the absence of a ligand. Here, we examined the role of MST2 in the growth of ER-positive MCF-7 cells. Cell cycle, apoptosis, and mammosphere formation assay method were implemented to detect the biological effects of MST2 ablation on the growth of MCF-7 cells in vitro. The effect of MST2-siRNA on MCF-7 cells tumor growth in vivo was studied in tumo...
Source: Toxicology and Applied Pharmacology - September 28, 2020 Category: Toxicology Authors: Park J, Kim GH, Lee J, Phuong BTC, Kong B, Won JE, Won GW, Lee YH, Han HD, Lee Y Tags: Toxicol Appl Pharmacol Source Type: research

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