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Source: Inflammation
Infectious Disease: Gastroenteritis
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MerTK Downregulates Lipopolysaccharide-Induced Inflammation Through SOCS1 Protein but Does Not Affect Phagocytosis of Escherichia coli in Macrophages
AbstractBacterial lipopolysaccharide (LPS) induces inflammatory responsevia toll-like receptor 4 (TLR4). However, this response must be strictly regulated because unbalanced overproduction of pro-inflammatory cytokines can lead to tissue damage and even be fatal. Herein, we explore whether Mer receptor tyrosine kinase (MerTK) regulatesEscherichia coli (E.coli) LPS-induced inflammation and mediates phagocytosis ofE.coli by macrophages. The results showed that LPS activated TLR4 signaling pathway and induced MerTK pathway in RAW264.7 macrophages, including suppressor of cytokine signaling1 (SOCS1). Preincubation with MerTK-s...
Source: Inflammation - August 24, 2018 Category: Allergy & Immunology Source Type: research
