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Source: Inflammation
Condition: Poisoning
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Total 2 results found since Jan 2013.
Tenascin-C Participates Pulmonary Injury Induced by Paraquat Through Regulating TLR4 and TGF- β Signaling Pathways
This study was conducted to investigate the role of Tenascin-C (TNC) in paraquat (PQ)-induced lung injuryin vivo andin vitro and explore its related mechanism during this process. Six- to eight-week-old male C57BL/6 mice were injected with 30 mg/kg PQ by intraperitoneal injection and sacrificed on 2 days, 7 days, 14 days, and 28 days after PQ administration.In vivo, we detected the expression of TNC at all time points of lung tissues in mice by reverse transcription-quantitative-polymerase chain reaction, western blotting, and immunohistochemistry. Expression of TLR4, NF- κB p65, TGF-β1, and α-SMA in lung tissues...
Source: Inflammation - August 31, 2021 Category: Allergy & Immunology Source Type: research
