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Source: Experimental Cell Research
Condition: Chronic Kidney Disease
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Total 3 results found since Jan 2013.
Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/ β-catenin pathway
Exp Cell Res. 2021 Jun 25:112713. doi: 10.1016/j.yexcr.2021.112713. Online ahead of print.ABSTRACTObesity, a global epidemic, is one of the critical causes of chronic kidney disease (CKD). R-spondin1 (RSPO1) possessing the potential to activate Wnt/β-catenin pathway was reported to be elevated in circulation of obesity objects. However, the function of RSPO1 and the latent mechanism in obesity-related CKD are still left to be revealed. In the present study, renal RSPO1 expression was increased in mice fed on high-fat diet (HFD) for 12 weeks. Lentivirus-mediated RSPO1 knockdown partly recovered obesity-related metabolic sy...
Source: Experimental Cell Research - June 28, 2021 Category: Cytology Authors: Xuesong Su Guangyu Zhou Mi Tian Si Wu Yanqiu Wang Source Type: research
miR-125b/Ets1 axis regulates transdifferentiation and calcification of vascular smooth muscle cells in a high-phosphate environment.
CONCLUSION: Our study suggests that down-regulation of miR-125b after β-glycerophosphoric acid treatment facilitates VSMCs transdifferentiation and calcification through targeting Ets1.
PMID: 24486760 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - January 30, 2014 Category: Cytology Authors: Wen P, Cao H, Fang L, Ye H, Zhou Y, Jiang L, Su W, Xu H, He W, Dai C, Yang J Tags: Exp Cell Res Source Type: research
