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The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF- κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65RelA-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability. Virology. 2019 Jul 03;535:83-101 Authors: Malu A, Hutchison T, Yapindi L, Smith K, Nelson K, Bergeson R, Pope J, Romeo M, Harrod C, Ratner L, Van Lint C, Harrod R Abstract Genomic instability is a hallmark of many cancers; however, the molecular etiology of chromosomal dysregulation is not well understood. The human T-cell leukemia virus type-1 (HTLV-1) oncoprotein Tax activates NF-κB-signaling and induces DNA-damage and aberrant ...
Source: Virology - July 2, 2019 Category: Virology Authors: Malu A, Hutchison T, Yapindi L, Smith K, Nelson K, Bergeson R, Pope J, Romeo M, Harrod C, Ratner L, Van Lint C, Harrod R Tags: Virology Source Type: research