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A Role for the Non-receptor Tyrosine Kinase ACK1 in TNF-alpha-mediated Apoptosis and Proliferation in Human Intestinal Epithelial Caco-2 Cells.
CONCLUSION: Our results demonstrate that ACK1 plays an important role in modulating TNF-alpha-induced aberrant cell proliferation and apoptosis, mediated in part by ACK1 activation. ACK1 and its down-stream effectors may hold promise as therapeutic targets in the prevention and treatment of gastrointestinal cancers, in particular, those induced by chronic intestinal inflammation. PMID: 28921811 [PubMed - as supplied by publisher]
Source: Cell Biology International - September 16, 2017 Category: Cytology Authors: Zhao X, Lv C, Chen S, Zhi F Tags: Cell Biol Int Source Type: research