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Aggravated Intestinal Apoptosis by ClC-3 Deletion is Lethal to Mice Endotoxemia.
Abstract Our previous study found that ClC-3 chloride channel functioned differently in the vascular and intestinal inflammation, the loss of ClC-3 reduced vascular inflammation but exacerbated intestinal inflammation. To furtherly clarify the role of ClC-3 chloride channels in systemic inflammation, we used LPS-induced endotoxemia model to investigate the response of wild-type and ClC-3 knockout mice to systemic inflammation. The results showed that in the LPS-induced endotoxemia model, the mortality of mice with ClC-3 deletion was significantly higher than that of wild-type mice. The liver and lung inflammations...
Source: Cell Biology International - July 4, 2018 Category: Cytology Authors: Huang LY, Li YJ, Li PP, Li HC, Ma P Tags: Cell Biol Int Source Type: research