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PSPH induces cell autophagy and promotes cell proliferation and invasion in the hepatocellular carcinoma cell line Huh7 via the AMPK/mTOR/ULK1 signaling pathway.
In conclusion, PSPH could induce autophagy, promote proliferation and invasion, and inhibit apoptosis in HCC cell via the AMPK/mTOR/ULK1 signaling pathway. This article is protected by copyright. All rights reserved. PMID: 33079432 [PubMed - as supplied by publisher]
Source: Cell Biology International - October 20, 2020 Category: Cytology Authors: Zhang J, Wang E, Zhang L, Zhou B Tags: Cell Biol Int Source Type: research

Calpains are required for invasive and metastatic potentials of human HCC cells.
Abstract Calpains are a conserved family of calcium-dependent cysteine proteinases involved in various cellular functions. Two ubiquitous isoforms, µ- and m-calpain, are key members of the calpain family that play essential roles in regulating cell migration and invasion. However, it remains unclear whether they are involved in the progression of hepatocellular carcinoma (HCC). Here, we investigated the functions of µ- and m-calpain in the invasive and metastatic processes of human hepatoma cells. Our results indicated that the expression levels of calpains were elevated in HCC cells compared with those in norma...
Source: Cell Biology International - June 7, 2013 Category: Cytology Authors: Chen B, Tang J, Guo YS, Li Y, Chen ZN, Jiang JL Tags: Cell Biol Int Source Type: research